Evidence map›Paper›PMID 32786283›Full record

ArticleACS infectious diseases2020

Peptide Probes of Colistin Resistance Discovered via Chemically Enhanced Phage Display.

Michael Kelly, Samantha Cambray, Kelly A McCarthy, Wenjian Wang, Edward Geisinger, Juan Ortiz-Marquez, Tim van Opijnen, Jianmin Gao

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Virulence · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael KellyDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Samantha CambrayDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Kelly A McCarthyDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID 0000-0003-0953-030X
Wenjian WangDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Edward GeisingerDepartment of Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Juan Ortiz-MarquezDepartment of Biology, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Tim van OpijnenDepartment of Biology, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Jianmin GaoDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID 0000-0001-9341-1287
Boston College · USNortheastern University · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
The bacterial response to antibiotics and the evolution of antibiotic resistanceR01AI110724 · NIAID · BOSTON COLLEGE · PI VAN OPIJNEN, TIM · 2015 to 2019
$2.0M
Novel Phage Display Platforms to Overcome Colistin ResistanceR01GM124231 · NIGMS · BOSTON COLLEGE · PI GAO, JIANMIN · 2019 to 2022
$1.2M
NIAID NIH HHS R01 AI110724NIAID NIH HHS U01 AI124302NIGMS NIH HHS R01 GM124231
6 · The paper itself

Abstract

Colistin is an antibiotic of last resort used to treat infections caused by multidrug-resistant Gram-negative bacterial pathogens. The recent surge in reported cases of colistin-resistant infections urgently calls for fast and reliable diagnostic methods, which can be used for the facile detection and proper treatment of these challenging infections. A major mechanism of colistin resistance involves phosphoethanolamine (PE) modification of lipopolysaccharide (LPS), the molecular target of colistin. This LPS modification mechanism has been recently reported to be transferrable via a plasmid-carried

Indexed as

BacteriophagesColistinAnti-Bacterial AgentsDrug Resistance, BacterialPeptidesAnti-Bacterial AgentsColistinPeptidescolistin resistancecovalent bindingiminoboronatesmcr-1peptide probesphage display

Identifiers

PMID32786283
PMCPMC8082519
OpenAlexW3046657040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.