Evidence map›Paper›PMID 32786258›Full record

ArticleACS chemical biology2020

Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels.

Christina Tzitzoglaki, Kelly McGuire, Panagiotis Lagarias, Athina Konstantinidi, Anja Hoffmann, Natalie A Fokina, Chulong Ma, Ioannis P Papanastasiou, Peter R Schreiner, Santiago Vázquez and 4 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. New type of RNA virus replication inhibitor based on decahydro-closo-decaborate anion containing amino acid ester pendant group.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Christina TzitzoglakiSection of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, Athens 15771, Greece.
Kelly McGuireDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, United States.
Panagiotis LagariasSection of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, Athens 15771, Greece.
Athina KonstantinidiSection of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, Athens 15771, Greece.
Anja HoffmannJena University Hospital, Department of Medical Microbiology, Section Experimental Virology, Hans Knoell Str. 2, D-07745 Jena, Germany.
Natalie A FokinaInstitute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Chulong MaDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.
Ioannis P PapanastasiouSection of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, Athens 15771, Greece.ORCID 0000-0001-6974-2561
Peter R SchreinerInstitute of Organic Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.ORCID 0000-0002-3608-5515
Santiago VázquezLaboratori de Quı́mica Farmacèutica (Unitat Associada al CSIC), Departament de Farmacologia, Toxicologia i Quı́mica Terapèutica, Facultat de Farmàcia i Ciències de l'Alimentació, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Joan XXIII, 27-31, Barcelona 08028, Spain.ORCID 0000-0002-9296-6026
Michaela SchmidtkeJena University Hospital, Department of Medical Microbiology, Section Experimental Virology, Hans Knoell Str. 2, D-07745 Jena, Germany.
Jun WangDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-4845-4621
David D BusathDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, United States.
Antonios KolocourisSection of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis-Zografou, Athens 15771, Greece.ORCID 0000-0001-6110-1903
National and Kapodistrian University of Athens · GRBrigham Young University · USJena University Hospital · DEJustus-Liebig-Universität Gießen · DEUniversity of Arizona · USUniversitat de Barcelona · ES

Funding

Drug Discovery Targeting the Influenza A Virus M2-S31N Proton ChannelR33AI119187 · NIAID · UNIVERSITY OF ARIZONA · PI PEREZ, DANIEL R, WANG, JUN · 2017 to 2019
$1.2M
Discovery of broad-spectrum influenza antivirals with a high genetic barrier to drug resistance by targeting the viral polymeraseR21AI144887 · NIAID · UNIVERSITY OF ARIZONA · PI WANG, JUN · 2019 to 2020
$415k
NIAID NIH HHS R21 AI144887NIAID NIH HHS R33 AI119187
6 · The paper itself

Abstract

We report on using the synthetic aminoadamantane-CH

Indexed as

AdamantaneBetacoronavirusBinding SitesCells, CulturedChloroquineCoronavirus InfectionsCOVID-19Genetic VariationHumansInfluenza A virusInfluenza, HumanIon ChannelsKineticsMolecular ProbesPandemicsPneumonia, ViralAdamantaneChloroquineIon ChannelsM2 protein, Influenza A virusMolecular ProbesViral Matrix ProteinsViroporin Proteins

Identifiers

PMID32786258
PMCPMC8051587
OpenAlexW3048808560

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.