Evidence map›Paper›PMID 32786174›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Bacterial products in donor airways prevent the induction of lung transplant tolerance.

Satona Tanaka, Jason M Gauthier, Yuriko Terada, Tsuyoshi Takahashi, Wenjun Li, Kohei Hashimoto, Ryuji Higashikubo, Ramsey R Hachem, Ankit Bharat, Jon H Ritter and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Tolerogenic lung allograft microenvironment suppresses pathogenic tissue remodeling following respiratory virus infection in mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  5. Article
  6. Clinical transplantation and research · 2024
    Review
  7. Article
  8. Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Innate immunity in lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Satona TanakaDepartment of Surgery, Washington University, Saint Louis, Missouri.ORCID 0000-0002-0789-2350
Jason M GauthierDepartment of Surgery, Washington University, Saint Louis, Missouri.ORCID 0000-0003-3326-8727
Yuriko TeradaDepartment of Surgery, Washington University, Saint Louis, Missouri.
Tsuyoshi TakahashiDepartment of Surgery, Washington University, Saint Louis, Missouri.
Wenjun LiDepartment of Surgery, Washington University, Saint Louis, Missouri.
Kohei HashimotoDepartment of Surgery, Washington University, Saint Louis, Missouri.
Ryuji HigashikuboDepartment of Surgery, Washington University, Saint Louis, Missouri.
Ramsey R HachemDepartment of Medicine, Washington University, Saint Louis, Missouri.
Ankit BharatDepartment of Surgery, Northwestern University, Chicago, Illinois.ORCID 0000-0002-1248-0457
Jon H RitterDepartment of Pathology & Immunology, Washington University, Saint Louis, Missouri.
Ruben G NavaDepartment of Surgery, Washington University, Saint Louis, Missouri.
Varun PuriDepartment of Surgery, Washington University, Saint Louis, Missouri.
Alexander S KrupnickDepartment of Surgery, University of Maryland, Baltimore, Maryland.ORCID 0000-0002-1790-6197
Andrew E GelmanDepartment of Surgery, Washington University, Saint Louis, Missouri.ORCID 0000-0002-0711-6343
Daniel KreiselDepartment of Surgery, Washington University, Saint Louis, Missouri.ORCID 0000-0002-7711-8651
Washington University in St. Louis · USNorthwestern University · USUniversity of Maryland, Baltimore · US

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Daniel Kreisel · 2015 to 2026
$19.4M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
The Role of Eosinophils in the Lung AllograftR01AI145108 · NIAID · UNIVERSITY OF VIRGINIA · PI Elizabeth A Jacobsen, ALEXANDER S. KRUPNICK · 2019 to 2026
$4.1M
The Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6M
Innate Immune Mechanisms of Ischemia Reperfusion Injury Following Cardiac TransplantationF32HL143950 · NHLBI · WASHINGTON UNIVERSITY · PI GAUTHIER, JASON MICHAEL · 2018 to 2018
$60k
Leukocyte trafficking in thoracic graftsI01BX002730 · VA · ST. LOUIS VA MEDICAL CENTER · PI KREISEL, DANIEL · 2016 to 2025
–
BLRD VA I01 BX002730NHLBI NIH HHS F32 HL143950NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL151078NIAID NIH HHS P01 AI116501NIAID NIH HHS R01 AI145108VA 1I01BX002730
6 · The paper itself

Abstract

Although postoperative bacterial infections can trigger rejection of pulmonary allografts, the impact of bacterial colonization of donor grafts on alloimmune responses to transplanted lungs remains unknown. Here, we tested the hypothesis that bacterial products present within donor grafts at the time of implantation promote lung allograft rejection. Administration of the toll-like receptor 2 (TLR2) agonist Pam

Indexed as

Lung TransplantationTransplantation ToleranceAnimalsGraft RejectionLungMiceMice, Inbred BALB CMice, Inbred C57BLMice, Knockout

Identifiers

PMID32786174
PMCPMC7775268
OpenAlexW3048701336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.