Evidence map›Paper›PMID 32786152›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Evidence of potent humoral immune activity in COVID-19-infected kidney transplant recipients.

Susan Hartzell, Sofia Bin, Claudia Benedetti, Meredith Haverly, Lorenzo Gallon, Gianluigi Zaza, Leonardo V Riella, Madhav C Menon, Sander Florman, Adeeb H Rahman and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. COVID-19 and solid organ transplantation: Finding the right balance.Transplantation reviews (Orlando, Fla.) · 2022
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Screening for antibodies to HLA class I in apheresis donors following Covid-19 or SARS-CoV-2 vaccination.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2022
    Article
  17. Article
  18. An overview of COVID-19 in solid organ transplantation.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Susan HartzellDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-4175-4602
Sofia BinDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7120-3866
Claudia BenedettiDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-9306-1424
Meredith HaverlyDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lorenzo GallonDepartment of Medicine, Division of Nephrology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Gianluigi ZazaRenal Unit, Department of Medicine, University Hospital of Verona, Verona, Italy.ORCID 0000-0002-6004-6196
Leonardo V RiellaTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-7636-3196
Madhav C MenonDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9567-4299
Sander FlormanRecanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, USA.ORCID 0000-0002-1635-9136
Adeeb H RahmanHuman Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
John M LeechHuman Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Peter S HeegerDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-4673-6913
Paolo CravediDepartment of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7837-0923
Icahn School of Medicine at Mount Sinai · USBrigham and Women's Hospital · USMount Sinai Hospital · USNorthwestern University · USUniversity of Verona · IT

Funding

Erythropoietin mediated immunoregulation in murine lupus nephritisR01AI132949 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRAVEDI, PAOLO · 2018 to 2022
$2.1M
National Institute of Allergy and Infectious Diseases R01 AI132949-02
6 · The paper itself

Abstract

Whether kidney transplant recipients are capable of mounting an effective anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. Herein, we analyzed peripheral blood cell surface and intracellular cytokine phenotyping by flow cytometry along with serum antibody testing in 18 kidney transplant recipients with active coronavirus disease 2019 (COVID-19) infection and 36 matched, transplanted controls without COVID-19. We observed significantly fewer total lymphocytes and fewer circulating memory CD4

Indexed as

Immunity, HumoralImmunocompromised HostPandemicsTransplant RecipientsCD8-Positive T-LymphocytesComorbidityCOVID-19FemaleHumansKidney TransplantationMaleMiddle AgedRenal InsufficiencyRetrospective StudiesSARS-CoV-2United Statesimmune regulationimmunobiologyimmunosuppressant - otherimmunosuppression/immune modulationinfection and infectious agents - viralkidney transplantation/nephrologytranslational research/science

Identifiers

PMID32786152
PMCPMC7436882
OpenAlexW3048465663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.