Evidence map›Paper›PMID 32786033›Full record

ReviewClinical and experimental dermatology2021

Literature mapping: association of microscopic skin microflora and biomarkers with macroscopic skin health.

X Li, L Xing, R Lai, C Yuan, P Humbert

Abstract readReview
In one paragraph

Review in Clinical and experimental dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

X LiClinical Science APAC, Johnson & Johnson (China) Ltd, Shanghai Technology and Research Center, Shanghai, China.ORCID https://orcid.org/0000-0002-2977-2624
L XingClinical Science APAC, Johnson & Johnson (China) Ltd, Shanghai Technology and Research Center, Shanghai, China.
R LaiExternal Innovation, Johnson & Johnson (China) Ltd, Minhang District, Shanghai, China.
C YuanSkin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Shanghai, China.
P HumbertDepartment of Dermatology, Research and Clinic Centre on the Tegument, Clinical Investigation Center, Besançon University Hospital, Besançon, France.

Funding

Johnson & Johnson
6 · The paper itself

Abstract

Associations between skin microbes or biomarkers and pathological conditions have been reported in the literature. However, there is a lack of clarity on the interaction between the coexistence of common skin microbes with skin physiology and subsequent development of clinical symptoms, and the role of biomarkers in mediating these changes before the development of skin disease. In this review, we aim to identify areas in which extensive research for the studied factors has already been conducted, and which research areas are under-represented. The SciFinder database was searched for articles containing key words including specific skin microbes, biomarkers, skin physiology and diseases from the beginning of the SciFinder data record to 26 April 2016, and we included an additional relevant recent publication from our group. Among the 8000 + articles selected, the frequency of keyword pairs between two roles [microscopic markers (microflora or biomarkers) and reactions (skin physiology or clinical symptoms, or skin disease)] was investigated. Associated research between the individual factors such as skin microflora or biomarkers (chosen based on our earlier publication) and specific biophysical parameters, symptoms or skin disease was identified. The present research heatmap emphasizes the significance of a structured review of research on concerned factor associations to identify early/subclinical clues that can be used to prevent progression to overt skin disease with the help of precise skin care or early intervention, as indicated by skin microflora, biomarkers and an interactive skin biophysics profile. The findings provide a novel approach to explore such associations and may guide future research directed towards predicting disease from early/subclinical symptoms.

Indexed as

BiomarkersSkin Physiological PhenomenaHumansSkinSkin DiseasesBiomarkers

Identifiers

PMID32786033
PMCPMC7754415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.