ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2020
Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis to explain unknown causes of the origins of SARS-COV-2.Environmental research · 2022Pooled it
- Biosafety, biosecurity, and bioethics.Monash bioethics review · 2024Review
- Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.International journal of biological macromolecules · 2022Article
- Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13.Microbiology spectrum · 2022Article
- There is no "origin" to SARS-CoV-2.Environmental research · 2022Article
- Origin of COVID-19: Dismissing the Mojiang mine theory and the laboratory accident narrative.Environmental research · 2022Article
- Thus spoke peptides: SARS-CoV-2 spike gene evolved in humans and then shortly in rats while the rest of its genome in horseshoe bats and then in treeshrews.Communicative & integrative biology · 2022Article
- Host Manipulation Mechanisms of SARS-CoV-2.Acta biotheoretica · 2021Article
- An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2.Lancet (London, England) · 2021Article
- What we know and what we need to know about the origin of SARS-CoV-2.Environmental research · 2021Article
- Article
- Review
- The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Article
- Should we discount the laboratory origin of COVID-19?Environmental chemistry letters · 2021Article
- Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review.Environmental chemistry letters · 2021Review
- Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2020Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite claims from prominent scientists that SARS-CoV-2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy-makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual-use gain-of-function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS-CoV-2's distinctive spike-protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus's origins and a re-examination of the risks and rewards of dual-use gain-of-function research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.