ArticleRice (New York, N.Y.)2020
UvAtg8-Mediated Autophagy Regulates Fungal Growth, Stress Responses, Conidiation, and Pathogenesis in Ustilaginoidea virens.
Article in Rice (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review).Molecular medicine reports · 2026Review
- A comprehensive exploration of molecular aspects of rice-Ustilaginoidea virens interactions.Plant molecular biology · 2026Review
- CaSun1, a SUN family protein, governs the pathogenicity ofHorticulture research · 2025Article
- Bax Inhibitor MoBi-1 Is Required for Conidiation, Pathogenicity, and Stress Responses inJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptomic and metabolomic analyses unravel the different pathogenic mechanisms ofFrontiers in microbiology · 2025Article
- The Bacteria-Derived dsRNA Was Used for Spray-Induced Gene Silencing for Rice False Smut Control.Journal of agricultural and food chemistry · 2024Article
- UvVelC is important for conidiation and pathogenicity in the rice false smut pathogenVirulence · 2024Article
- PlAtg8-mediated autophagy regulates vegetative growth, sporangial cleavage, and pathogenesis inMicrobiology spectrum · 2024Article
- Transcriptome analysis highlights the influence of temperature on hydrolase and traps in nematode-trapping fungi.Frontiers in microbiology · 2024Article
- Sucrose non-fermenting protein kinase geneVirulence · 2023Article
- UvSnx4 is required for conidiation, pathogenicity and stress responses by regulating mitophagy and macroautophagy in Ustilaginoidea virens.Crop health · 2023Article
- Phyllosphere microbiome induces host metabolic defence against rice false-smut disease.Nature microbiology · 2023Article
- Transcriptomic and Metabolomic Analyses Provide Insights into the Pathogenic Mechanism of the Rice False Smut PathogenInternational journal of molecular sciences · 2023Article
- Quantitative Loop-Mediated Isothermal Amplification Detection ofInternational journal of molecular sciences · 2023Article
- UvATG6 Interacts with BAX Inhibitor 1 Proteins and Plays Critical Roles in Growth, Conidiation, and Virulence inMicrobiology spectrum · 2023Article
- HOG1 Mitogen-Activated Protein Kinase Pathway-Related Autophagy Induced by HJournal of fungi (Basel, Switzerland) · 2023Article
- Hyphal Fusions Enable Efficient Nutrient Distribution inMicroorganisms · 2022Article
- UvKmt2-Mediated H3K4 Trimethylation Is Required for Pathogenicity and Stress Response inJournal of fungi (Basel, Switzerland) · 2022Article
- Identification of Long Non-Coding RNAs and Their Target Genes from Mycelium and Primordium in Model MushroomMycobiology · 2022Article
- UvKmt6-mediated H3K27 trimethylation is required for development, pathogenicity, and stress response inVirulence · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUstilaginoidea virens has become one of the most devastating rice pathogens in China, as well as other rice-growing areas. Autophagy is an important process in normal cell differentiation and development among various organisms. To date, there has been no optimized experimental system introduced for the study of autophagy in U. virens. In addition, the function of autophagy in pathogenesis remains unknown in U. virens. Therefore, the functional analyses of UvAtg8 may potentially shed some light on the regulatory mechanism and function of autophagy in U. virens.
resultsIn this study, we characterized the functions of UvAtg8, which is a homolog of Saccharomyces cerevisiae ScAtg8, in the rice false smut fungus U. virens. The results showed that UvATG8 is essential for autophagy in U. virens. Also, the GFP-UvATG8 strain, which could serve as an appropriate marker for monitoring autophagy in U. virens, was generated. Furthermore, this study found that the ΔUvatg8 mutant was defective in the vegetative growth, conidiation, adaption to oxidative, hyperosmotic, cell wall stresses, and production of toxic compounds. Pathogenicity assays indicated that deletion of UvATG8 resulted in significant reduction in virulence of U. virens. Further microscopic examinations of the infection processes revealed that the severe virulence defects in the ∆Uvatg8 were mainly caused by the highly reduced conidiation and secondary spore formation.
conclusionsOur results indicated that the UvAtg8 is necessary for the fungal growth, stresses responses, conidiation, secondary spore formation, and pathogenicity of U. virens. Moreover, our research finding will potentially assist in further clarifying the molecular mechanism of U. virens infection, as well as provide a good marker for autophagy in U. virens and a good reference value for the further development of effective fungicides based on gene targeting.
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