ArticleAnnals of biomedical engineering2021
Investigation of Alterations in the Lumbar Disc Biomechanics at the Adjacent Segments After Spinal Fusion Using a Combined In Vivo and In Silico Approach.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Real-Time Prediction of Lumbar Spine Stress and Displacement Using a Proof-of-Concept Digital Twin Biomechanical Model.Annals of biomedical engineering · 2026Article
- The Etiology and Treatment of Failed Back Surgery Syndrome in Patients with Primary Lumbar Fixation.Journal of orthopaedic case reports · 2026Article
- Utilization of Total Posterior Spine System facet arthroplasty for management of adjacent segment disease following lumbar spinal fusion: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Can Wallis topping-off surgery reduce radiographic adjacent segment degeneration? a single-center study with at least 8 years of long-term follow-up.BMC musculoskeletal disorders · 2025Article
- The Relationship Between Postoperative Variation of Adjacent Segment Three-Dimensional Kinematics and Postoperative PI-LL in Patients With Degenerative Lumbar Scoliosis After Short Segment Fixation.Orthopaedic surgery · 2025Article
- Single-View Fluoroscopic X-Ray Pose Estimation: A Comparison of Alternative Loss Functions and Volumetric Scene Representations.Journal of imaging informatics in medicine · 2025Article
- A perspective on reoperations after surgical treatments of degenerative lumbar diseases.Journal of orthopaedic translation · 2025Review
- An OLIF Cage Integrated with a Low-Profile Plate and Cross Screws Could Reduce the Risk of Postoperative Complications Biomechanically.Annals of biomedical engineering · 2025Article
- Article
- Comparison of Clinical Efficacy in the Treatment of Lumbar Degenerative Disease: Posterior Lumbar Interbody Fusion, Posterior Lumbar Fusion, and Hybrid Surgery.International journal of spine surgery · 2024Article
- Biomechanical analysis of adjacent segments after correction surgery for adult idiopathic scoliosis: a finite element analysis.Scientific reports · 2024Article
- Effects of dynamic and rigid implantation on biomechanical characteristics of different sagittal alignment lumbar after single- or double-level spinal fixations: a finite-element modeling study.European journal of medical research · 2023Article
- A correlation study of preoperative lumbar paraspinal muscle quality and L5-S1 lumbar foraminal stenosis degeneration after L4-5 TLIF.Journal of orthopaedic surgery and research · 2023Article
- A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs.Annals of biomedical engineering · 2023Article
- Fixation-induced surgical segment's high stiffness and the damage of posterior structures together trigger a higher risk of adjacent segment disease in patients with lumbar interbody fusion operations.Journal of orthopaedic surgery and research · 2023Article
- Influence of Sagittal Lumbopelvic Morphotypes on the Range of Motion of Human Lumbar Spine: An In Vitro Cadaveric Study.Bioengineering (Basel, Switzerland) · 2022Article
- Biomechanical comparative analysis of effects of dynamic and rigid fusion on lumbar motion with different sagittal parameters: AnFrontiers in bioengineering and biotechnology · 2022Article
- Will the adjustment of insertional pedicle screw positions affect the risk of adjacent segment diseases biomechanically? An in-silico study.Frontiers in surgery · 2022Article
- Transfer learning from an artificial radiograph-landmark dataset for registration of the anatomic skull model to dual fluoroscopic X-ray images.Computers in biology and medicine · 2021Article
- Biomechanical effects of lumbar fusion surgery on adjacent segments using musculoskeletal models of the intact, degenerated and fused spine.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of adjacent segment degeneration (ASD) is a major concern after lumbar spinal fusion surgery, but the causative mechanisms remain unclear. This study used a combined in vivo and in silico method to investigate the changes of anatomical dimensions and biomechanical responses of the adjacent segment (L3-4) after spinal fusion (L4-S1) in five patients under weight-bearing upright standing conditions. The in vivo adjacent disc height changes before and after fusion were measured using a dual fluoroscopic imaging system (DFIS), and the measured in vivo intervertebral positions and orientations were used as displacement boundary conditions of the patient-specific three-dimensional (3D) finite element (FE) disc models to simulate the biomechanical responses of adjacent discs to fusion of the diseased segments. Our data (represented by medians and 95% confidence intervals) showed that a significant decrease by - 0.8 (- 1.2, - 0.4) mm (p < 0.05) in the adjacent disc heights occurred at the posterior region after fusion. The significant increases in disc tissue strains and stresses, 0.32 (0.21, 0.43) mm/mm (p < 0.05) and 1.70 (1.07, 3.60) MPa (p < 0.05), respectively, after fusion were found in the posterolateral portions of the outermost annular lamella. The intradiscal pressure of the adjacent disc was significantly increased by 0.29 (0.13, 0.47) MPa after fusion (p < 0.05). This study demonstrated that fusion could cause alterations in adjacent disc biomechanics, and the combined in vivo and in silico method could be a valuable tool for the quantitative assessment of ASD after fusion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.