Evidence map›Paper›PMID 32785827›Full record

ReviewInflammopharmacology2020

Salt-dependent hypertension and inflammation: targeting the gut-brain axis and the immune system with Brazilian green propolis.

Marcos Adriano Carlos Batista, Daiane Cristina de Assis Braga, Sandra Aparecida Lima de Moura, Gustavo Henrique Bianco de Souza, Orlando David Henrique Dos Santos, Leonardo Máximo Cardoso

Abstract readReview
In one paragraph

Review in Inflammopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcos Adriano Carlos BatistaDepartment of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.ORCID http://orcid.org/0000-0002-4725-0790
Daiane Cristina de Assis BragaDepartment of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.ORCID http://orcid.org/0000-0001-8125-8035
Sandra Aparecida Lima de MouraDepartment of Environmental Engineering, Mines School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.ORCID http://orcid.org/0000-0002-3406-0437
Gustavo Henrique Bianco de SouzaDepartment of Pharmacy, Pharmacy School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.ORCID http://orcid.org/0000-0002-1548-3274
Orlando David Henrique Dos SantosDepartment of Pharmacy, Pharmacy School, Federal University of Ouro Preto, Ouro Preto, MG, Brazil.ORCID http://orcid.org/0000-0002-8904-6990
Leonardo Máximo CardosoDepartment of Biological Sciences, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Morro Do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil. leonardo.cardoso@ufop.edu.br.ORCID http://orcid.org/0000-0001-9821-0484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic arterial hypertension (SAH) is a major health problem around the world and its development has been associated with exceeding salt consumption by the modern society. The mechanisms by which salt consumption increase blood pressure (BP) involve several homeostatic systems but many details have not yet been fully elucidated. Evidences accumulated over the last 60 decades raised the involvement of the immune system in the hypertension development and opened a range of possibilities for new therapeutic targets. Green propolis is a promising natural product with potent anti-inflammatory properties acting on specific targets, most of them participating in the gut-brain axis of the sodium-dependent hypertension. New anti-hypertensive products reinforce the therapeutic arsenal improving the corollary of choices, especially in those cases where patients are resistant or refractory to conventional therapy. This review sought to bring the newest advances in the field articulating evidences that show a cross-talking between inflammation and the central mechanisms involved with the sodium-dependent hypertension as well as the stablished actions of green propolis and some of its biologically active compounds on the immune cells and cytokines that would be involved with its anti-hypertensive properties.

Indexed as

AnimalsAntihypertensive AgentsAnti-Inflammatory AgentsBrainBrazilGastrointestinal TractHumansHypertensionImmune SystemInflammationPropolisSodium Chloride, DietaryAntihypertensive AgentsAnti-Inflammatory AgentsPropolisSodium Chloride, DietaryCytokinesGreen propolisHypertensionInflammationSodiumSympathetic drive

Identifiers

PMID32785827
PMCPMC8826348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.