ArticleIntensive care medicine experimental2020
Unloading using Impella CP during profound cardiogenic shock caused by left ventricular failure in a large animal model: impact on the right ventricle.
Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Right ventricular dysfunction in cardiogenic shock on temporary mechanical circulatory support.European heart journal open · 2026Article
- Right Ventricular Pressure-Volume Loop Analysis in Large Animal Research: A Scoping Review of Current Practices Using Conductance and Admittance Catheters.Pulmonary circulation · 2026Review
- Right Ventricular Longitudinal Strain Predicts Weaning Success in Cardiogenic Shock Patients Supported by a Microaxial Flow Pump.Critical care explorations · 2025Article
- Head-to-head comparison of V-A ECMO, Impella and ECPELLA in normal ovine hearts.Scientific reports · 2025Article
- Differential Effects of Pharmacologic and Mechanical Support on Right-Left Ventricular Coupling.Journal of cardiovascular translational research · 2024Article
- Comprehensive RV Hemodynamic Assessment With Pressure-Volume Analysis During Impella Support: Findings From the CHAMP-IMPELLA Study.JACC. Basic to translational science · 2024Article
- Monitoring a Mystery: The Unknown Right Ventricle during Left Ventricular Unloading with Impella in Patients with Cardiogenic Shock.Journal of clinical medicine · 2024Article
- Dynamic load modulation predicts right heart tolerance of left ventricular cardiovascular assist in a porcine model of cardiogenic shock.Science translational medicine · 2024Article
- Haemodynamic effects of inhaled nitric oxide in acute myocardial infarction complicated by right heart failure under ECPELLA support: case report.European heart journal. Case reports · 2023Article
- Review
- Fulminant myocarditis spreading from the right ventricle treated with extracorporeal membrane oxygenation and impella.BMJ case reports · 2022Article
- Influence of noise manipulation on retention in a simulated ICU ward round: an experimental pilot study.Intensive care medicine experimental · 2022Article
- Impella RP Versus Pharmacologic Vasoactive Treatment in Profound Cardiogenic Shock due to Right Ventricular Failure.Journal of cardiovascular translational research · 2021Article
- Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimThis study aimed to assess right ventricular (RV) function during cardiogenic shock due to acute left ventricular (LV) failure, including during LV unloading with Impella CP and an added moderate dose of norepinephrine.
methodsCardiogenic shock was induced by injecting microspheres in the left main coronary artery in 18 adult Danish Landrace pigs. Conductance catheters were placed in both ventricles and pressure-volume loops were recorded simultaneously.
resultsCardiogenic shock due to LV failure also impaired RV performance, which was partially restored during haemodynamic support with Impella CP, as demonstrated by changes in the ventriculo-arterial coupling (Ea/Ees ratio) (baseline (median [Q1;Q3]) 1.2 [1.1;1.6]), cardiogenic shock (3.0 [2.4;4.5]), Impella CP (2.1 [1.3;2.7]) (p
conclusionsThe Impella CP provided efficient LV unloading, improved RV function, and end-organ perfusion. Moderate doses of norepinephrine during Impella support further improved RV function, but at the expense of an increase in SW of the failing LV.
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Registered trials
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