ArticleJournal of materials chemistry. B2020
A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.
Article in Journal of materials chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.Advanced healthcare materials · 2026Article
- Advancing Drug Delivery: Design and Applications of MOF-Polyurethane Composites for Controlled Release Systems.ACS omega · 2025Review
- Highly Efficient Color Tuning of Lithium Niobate Nanostructures on Flexible Substrate.Materials (Basel, Switzerland) · 2025Article
- Polymeric Heart Valves: Do They Represent a Reliable Alternative to Current Prosthetic Devices?Polymers · 2025Review
- Review
- Improving the hemocompatibility of a porohyperelastic layered vascular graft using luminal reversal microflows.Journal of the mechanical behavior of biomedical materials · 2024Article
- Magnetically assisted soft milli-tools for occluded lumen morphology detection.Science advances · 2023Article
- Urushiol-Based Benzoxazine Containing Sulfobetaine Groups for Sustainable Marine Antifouling Applications.Polymers · 2023Article
- Synthesis and characterization of low surface energy thermoplastic polyurethane elastomers based on polydimethylsiloxane.RSC advances · 2023Article
- Zwitterionic Polysulfobetaine Coating and Antiplatelet Liposomes Reduce Fouling in Artificial Lung Circuits.Macromolecular bioscience · 2023Article
- Stability and Thrombogenicity Analysis of Collagen/Carbon Nanotube Nanocomposite Coatings Using a Reversible Microfluidic Device.Membranes · 2023Article
- Piranha solution treatment: A facile method for improving the antithrombotic ability and regulating smooth muscle cell growth on blood contact materials.Frontiers in bioengineering and biotechnology · 2023Article
- Challenge of material haemocompatibility for microfluidic blood-contacting applications.Frontiers in bioengineering and biotechnology · 2023Review
- Adaptive wireless millirobotic locomotion into distal vasculature.Nature communications · 2022Article
- Biomimetic materials based on zwitterionic polymers toward human-friendly medical devices.Science and technology of advanced materials · 2022Review
- Micellar Carriers of Active Substances Based on Amphiphilic PEG/PDMS Heterograft Copolymers: Synthesis and Biological Evaluation of Safe Use on Skin.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Polydimethylsiloxane (PDMS) is commonly used in medical devices because it is non-toxic and stable against oxidative stress. Relatively high blood platelet adhesion and the need for chemical crosslinking through curing, however, limit its utility. In this research, a biostable PDMS-based polyurethane-urea bearing zwitterion sulfobetaine (PDMS-SB-UU) was synthesized for potential use in the fabrication or coating of blood-contacting devices, such as a conduits, artificial lungs, and microfluidic devices. The chemical structure and physical properties of synthesized PDMS-SB-UU were confirmed by 1H-nuclear magnetic resonance (1H-NMR), X-ray diffraction (XRD), and uniaxial stress-strain curve. In vitro stability of PDMS-SB-UU was confirmed against lipase and 30% H2O2 for 8 weeks, and PDMS-SB-UU demonstrated significantly higher resistance to fibrinogen adsorption and platelet deposition compared to control PDMS. Moreover, PDMS-SB-UU showed a lack of hemolysis and cytotoxicity with whole ovine blood and rat vascular smooth muscle cells (rSMCs), respectively. The PDMS-SB-UU was successfully processed into small-diameter (0.80 ± 0.05 mm) conduits by electrospinning and coated onto PDMS- and polypropylene-based blood-contacting biomaterials due to its unique physicochemical characteristics from its soft- and hard- segments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.