Evidence map›Paper›PMID 32785154›Full record

ArticleCancers2020

Identification of Cancer-Associated Circulating Cells in Anal Cancer Patients.

Thomas J Carter, Jeyarooban Jeyaneethi, Juhi Kumar, Emmanouil Karteris, Rob Glynne-Jones, Marcia Hall

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas J CarterMount Vernon Cancer Centre, Middlesex HA6 2RN, UK.ORCID 0000-0001-5940-0146
Jeyarooban JeyaneethiDepartment of Life Sciences, Brunel University, London UB83PH, UK.
Juhi KumarDepartment of Life Sciences, Brunel University, London UB83PH, UK.
Emmanouil KarterisDepartment of Life Sciences, Brunel University, London UB83PH, UK.
Rob Glynne-JonesMount Vernon Cancer Centre, Middlesex HA6 2RN, UK.ORCID 0000-0002-6742-222X
Marcia HallMount Vernon Cancer Centre, Middlesex HA6 2RN, UK.ORCID 0000-0003-0039-5041

Funding

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6 · The paper itself

Abstract

Whilst anal cancer accounts for less than 1% of all new cancer cases, incidence rates have increased by up to 70% in the last 30 years with the majority of cases driven by human papilloma virus (HPV) infection. Standard treatment for localised anal cancer is chemoradiotherapy (CRT). Localised progression is the predominant pattern of relapse but well under 50% of cases are salvaged by surgery, predominantly because confirming recurrence within post-radiation change is very challenging. Identifying cancer-associated circulating cells (CCs) in peripheral blood could offer a corroborative method of monitoring treatment efficacy and identifying relapse early. To study this, nucleated cells were isolated from the blood of patients with anal cancer prior to, during, and after CRT and processed through the Amnis

Indexed as

anal cancercancer-associated circulating cellsHPVliquid biopsies

Identifiers

PMID32785154
PMCPMC7465059

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.