Evidence map›Paper›PMID 32785068›Full record

ArticleInternational journal of molecular sciences2020

Lithium Chloride Sensitivity in Yeast and Regulation of Translation.

Maryam Hajikarimlou, Kathryn Hunt, Grace Kirby, Sarah Takallou, Sasi Kumar Jagadeesan, Katayoun Omidi, Mohsen Hooshyar, Daniel Burnside, Houman Moteshareie, Mohan Babu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Maryam HajikarimlouDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0003-0762-3465
Kathryn HuntDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Grace KirbyDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Sarah TakallouDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Sasi Kumar JagadeesanDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Katayoun OmidiDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Mohsen HooshyarDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Daniel BurnsideDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Houman MoteshareieDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Mohan BabuDepartment of Biochemistry, Research and Innovation Centre, University of Regina, Regina, SK S4S 0A2, Canada.
Myron SmithDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Martin HolcikDepartment of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0002-1922-5299
Bahram SamanfarDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0001-6625-2153
Ashkan GolshaniDepartment of Biology and Ottawa Institute of Systems Biology, Carleton University, Ottawa, ON K1S 5B6, Canada.
Carleton University · CAAgriculture and Agri-Food Canada · CAUniversity of Regina · CA

Funding

Natural Sciences and Engineering Research Council of Canada 123456
6 · The paper itself

Abstract

For decades, lithium chloride (LiCl) has been used as a treatment option for those living with bipolar disorder (BD). As a result, many studies have been conducted to examine its mode of action, toxicity, and downstream cellular responses. We know that LiCl is able to affect cell signaling and signaling transduction pathways through protein kinase C and glycogen synthase kinase-3, which are considered to be important in regulating gene expression at the translational level. However, additional downstream effects require further investigation, especially in translation pathway. In yeast, LiCl treatment affects the expression, and thus the activity, of

Indexed as

5' Untranslated RegionsAmino Acyl-tRNA SynthetasesAntimanic AgentsBipolar DisorderGene Expression RegulationGene Knockout TechniquesLithium ChlorideOrganisms, Genetically ModifiedPhosphoglucomutaseProtein BiosynthesisRNA HelicasesRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal Transduction5' Untranslated RegionsAmino Acyl-tRNA SynthetasesAntimanic AgentsLithium ChlorideNAM7 protein, S cerevisiaePhosphoglucomutasePus2 protein, S cerevisiaeRNA HelicasesRNA, MessengerSaccharomyces cerevisiae Proteinsbipolar disordergene expressionlithium chloridemode of activityside effectstoxicitytranslationyeast

Identifiers

PMID32785068
PMCPMC7461102
OpenAlexW3048245137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.