Evidence map›Paper›PMID 32785021›Full record

Trial reportNutrients2020

A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.

Mats I Nilsson, Andrew Mikhail, Lucy Lan, Alessia Di Carlo, Bethanie Hamilton, Kristin Barnard, Bart P Hettinga, Erin Hatcher, Milla G Tarnopolsky, Joshua P Nederveen and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03536871 (Exercise and Nutritional Supplementation for Aging and Sedentary Lifestyles), which is not on this map. Cited by 53 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 10 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03536871 nacompletednot on this map

Exercise and Nutritional Supplementation for Aging and Sedentary Lifestyles

TypeinterventionalSponsorMcMaster UniversityRan2018 to 2019Enrolled45ConditionsSarcopenia, Healthy Elderly, Healthy YoungArmsmulti-nutrient supplement, Exercise
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 10 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  17. Nutrients · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Mats I NilssonDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0001-5656-5578
Andrew MikhailDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Lucy LanDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Alessia Di CarloDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Bethanie HamiltonDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Kristin BarnardDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Bart P HettingaExerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Erin HatcherDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Milla G TarnopolskyDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Joshua P NederveenDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Adam L BujakExerkine Corporation, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Linda MayDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.
Mark A TarnopolskyDepartment of Pediatrics, McMaster University Medical Center, Hamilton, ON L8N 3Z5, Canada.ORCID 0000-0003-0312-3746
McMaster University Medical Centre · CA

Funding

CIHR 143325CSRD VA 1
6 · The paper itself

Abstract

Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5,

Indexed as

Body CompositionDietary SupplementsMuscle StrengthResistance TrainingAgedAnabolic AgentsBody Fluid CompartmentsCaseinsCombined Modality TherapyCreatineDouble-Blind MethodExerciseFatty Acids, Omega-3HumansMaleMuscle Fibers, Fast-TwitchAnabolic AgentsCaseinsCreatineFatty Acids, Omega-3Muscle ProteinsVitamin DVitaminsWhey ProteinsCOVID-19creatinemulti-ingredient supplementomega-3randomized clinical trialresistance exercisesarcopeniavitamin Dwhey

Identifiers

PMID32785021
PMCPMC7468764
OpenAlexW3048059139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.