Evidence map›Paper›PMID 32784634›Full record

ArticleDentistry journal2020

Potential Advantages of Peroxoborates and Their Ester Adducts Over Hydrogen Peroxide as Therapeutic Agents in Oral Healthcare Products: Chemical/Biochemical Reactivity Considerations

Martin Grootveld, Edward Lynch, Georgina Page, Wyman Chan, Benita Percival, Eugenia Anagnostaki, Valina Mylona, Sonia Bordin-Aykroyd, Kerry L Grootveld

Open access · goldAbstract read
In one paragraph

Article in Dentistry journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Martin GrootveldLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0003-1502-3734
Edward LynchLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Georgina PageLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Wyman ChanLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Benita PercivalLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0002-8769-8979
Eugenia AnagnostakiLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0003-2835-695X
Valina MylonaLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0002-5212-5708
Sonia Bordin-AykroydLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Kerry L GrootveldLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
De Montfort University · GBUniversity of Nevada, Las Vegas · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxides present in oral healthcare products generally exert favourable protective activities against the development and progression of tooth decay, plaque, gingivitis, and halitosis, etc. However, despite the high level of research focus on hydrogen and carbamide peroxides as therapeutically active (and tooth-whitening) agents, to date the use of alternative chemical forms of peroxides such as peroxoborates for these purposes has received only scant attention. Intriguingly, peroxoborate and its esters with polyols, such as glycerol, have a very diverse chemistry/biochemistry in aqueous solution, for which there is an increasing amount of evidence that it remains distinctive from that of hydrogen peroxide; such properties include self-associative and hydrolytic equilibria, and their abilities to participate in electrophile- or nucleophile-scavenging, metal ion-complexing, redox and free radical reactions, for example. Therefore, the purpose of this detailed commentary is to evaluate both differences and similarities between the molecular/biomolecular reactivities of peroxoborate species and hydrogen peroxide

Indexed as

microbicidesoral healthcare productsoral malodoroxidantsperoxidesperoxoborateperoxoborate-polyol ester adductsreactive oxygen speciestooth-whitening products

Identifiers

PMID32784634
PMCPMC7559157
OpenAlexW3048134454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.