Evidence map›Paper›PMID 32784578›Full record

ArticleBioengineering (Basel, Switzerland)2020

Coupling of Fibrin Reorganization and Fibronectin Patterning by Corneal Fibroblasts in Response to PDGF BB and TGFβ1.

Miguel Miron-Mendoza, Dalia Vazquez, Nerea García-Rámila, Hikaru R Ikebe, W Matthew Petroll

Open access · goldAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Miguel Miron-MendozaDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Dalia VazquezDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Nerea García-RámilaDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Hikaru R IkebeDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
W Matthew PetrollDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Southwestern Medical CenterThe University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US

Funding

Assessment of Corneal Fibroblast Biomechanical BehaviorR01EY013322 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI PETROLL, W MATTHEW · 2001 to 2025
$9.0M
Stem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9M
NEI NIH HHS P30 EY030413NEI NIH HHS R01 EY013322NIH HHS P30 EY030413NIH HHS R01 EY013322Research to Prevent Blindness Unrestricted Departmental Grant
6 · The paper itself

Abstract

We previously reported that corneal fibroblasts within 3D fibrin matrices secrete, bind, and organize fibronectin into tracks that facilitate cell spreading and migration. Other cells use these fibronectin tracks as conduits, which leads to the development of an interconnected cell/fibronectin network. In this study, we investigate how cell-induced reorganization of fibrin correlates with fibronectin track formation in response to two growth factors present during wound healing: PDGF BB, which stimulates cell spreading and migration; and TGFβ1, which stimulates cellular contraction and myofibroblast transformation. Both PDGF BB and TGFβ1 stimulated global fibrin matrix contraction (

Indexed as

3-D matricescollective cell migrationcorneal fibroblastsfibrinfibronectin

Identifiers

PMID32784578
PMCPMC7552779
OpenAlexW3040768428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.