Evidence map›Paper›PMID 32784503›Full record

ReviewCells2020

Robustness during Aging-Molecular Biological and Physiological Aspects.

Emanuel Barth, Patricia Sieber, Heiko Stark, Stefan Schuster

Abstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emanuel BarthRNA Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0003-0803-8858
Patricia SieberMatthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-9631-1126
Heiko StarkInstitute of Zoology and Evolutionary Research with Phyletic Museum, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-6450-9744
Stefan SchusterMatthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0003-2828-9355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution.

Indexed as

AgingCellular SenescenceAnimalsBody TemperatureHematocritHumansImmunity, InnateOxidation-Reductionage-related diseasesfailure accumulationhealthy agingimmunosenescencerobustnesstheories of aging

Identifiers

PMID32784503
PMCPMC7465392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.