ReviewMicroorganisms2020
Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes.
Review in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- A sucralose-based sweetener promotes biofilm formation and plasmid-mediated antibiotic resistance transfer in opportunistic gut bacteria.Archives of microbiology · 2026Article
- Selective shifts in mobile antibiotic resistance genes under carbamazepine exposure in wastewater microbiomes.ISME communications · 2026Article
- Exploring the Relationship Between Farmland Management and Manure-Derived Antibiotic Resistance Genes and Their Prevention and Control Strategies.Antibiotics (Basel, Switzerland) · 2025Review
- The Environmental Lifecycle of Antibiotics and Resistance Genes: Transmission Mechanisms, Challenges, and Control Strategies.Microorganisms · 2025Review
- Phenotypic Detection of Extended-Spectrum β-Lactamase and Carbapenemase-ProducingAntibiotics (Basel, Switzerland) · 2025Article
- Tracking Enterobacteria, microbiomes, and antibiotic resistance genes from waste to soil with repeated compost applications.PloS one · 2025Article
- Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes.Critical reviews in microbiology · 2024Review
- Antimicrobial Resistance in Livestock: A Serious Threat to Public Health.Antibiotics (Basel, Switzerland) · 2024Review
- Host defense peptides mitigate the spread of antibiotic resistance in physiologically relevant condition.Antimicrobial agents and chemotherapy · 2024Article
- gcPathogen: a comprehensive genomic resource of human pathogens for public health.Nucleic acids research · 2024Article
- Extensively and multidrug-resistant bacterial strains: case studies of antibiotics resistance.Frontiers in microbiology · 2024Review
- Current examining methods and mathematical models of horizontal transfer of antibiotic resistance genes in the environment.Frontiers in microbiology · 2024Review
- Resensitizing multidrug-resistant Gram-negative bacteria to carbapenems and colistin using disulfiram.Communications biology · 2023Article
- Factors and Mechanisms Influencing Conjugation In Vivo in the Gastrointestinal Tract Environment: A Review.International journal of molecular sciences · 2023Review
- Characterizations ofFrontiers in microbiology · 2023Article
- Antimicrobial resistance genes and associated mobile genetic elements in Lactobacillales from various sources.Frontiers in microbiology · 2023Article
- Cooccurrence of Antibiotic Resistance and Hypervirulence in High-Risk Carbapenem-Resistant K14.K64 and Wzi209 Klebsiella pneumoniae Strains Driven by Plasmids and Their Derivatives.Microbiology spectrum · 2022Article
- Microbial Resistance to Antibiotics and Effective Antibiotherapy.Biomedicines · 2022Review
- Antimicrobial Peptides: From Design to Clinical Application.Antibiotics (Basel, Switzerland) · 2022Review
- Subinhibitory antibiotic concentrations promote the horizontal transfer of plasmid-borne resistance genes fromFrontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The global spread of antibiotic resistance has posed a serious threat to public healthcare and undermined decades of progress made in the fight against bacterial infections. It has been demonstrated that the lack of novel effective antibiotics and rapid spread of antibiotic resistance genes via horizontal transfer in the ecosystem are mainly responsible for this crisis. Notably, plasmid-mediated horizontal transfer of antibiotic resistance genes (ARGs) is recognized as the most dominant dissemination pathway of ARGs in humans, animals and environmental settings. Antibiotic selective pressure has always been regarded as one of the crucial contributors to promoting the dissemination of antibiotic resistance through horizontal gene transfer (HGT). However, the roles of exogenous compounds and particularly non-antibiotic drugs in the spread of ARGs are still underappreciated. In this review, we first summarize the major pathways of HGT in bacteria, including conjugation, transformation, transduction and vesiduction. Subsequently, an overview of these compounds capable of promoting the HGT is presented, which guides to the formulation of more reasonable dosing regimens and drug residue standards in clinical practice. By contrast, these compounds that display an inhibition effect on HGT are also highlighted, which provides a unique strategy to minimize the spread of ARGs. Lastly, we discuss the implementations and challenges in bringing these HGT inhibitors into clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.