ArticleBMJ (Clinical research ed.)2020
Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study.
Article in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Clinical outcomes of atrial fibrillation screening: a meta-analysis of randomized controlled trials.Annals of medicine · 2025Pooled it
- Electrical energy by electrode placement for cardioversion of atrial fibrillation: a systematic review and meta-analysis.Open heart · 2023Pooled it
- Outcome-Adaptive Lasso for Cox Proportional Hazards Model.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Electrical cardioversion for atrial fibrillation: nationwide trends in Denmark, 2010-2022.Open heart · 2026Article
- The Cost Utility of Rhythm Control Treatment Sequences in Patients with Atrial Fibrillation: Anti-arrhythmic Drugs Versus Catheter Ablation.PharmacoEconomics · 2026Article
- Temporal trends in associations between social drivers and life-years lost in newly diagnosed atrial fibrillation in Denmark, 2000-22: a nationwide cohort study.The Lancet. Public health · 2026Article
- Prediction of Atrial Fibrillation From the ECG in the Community Using Deep Learning: A Multinational Study.Circulation. Arrhythmia and electrophysiology · 2025Article
- Trends in mortality in people with heart failure and atrial fibrillation: a population-based cohort study.The lancet. Healthy longevity · 2025Article
- Temporal Trends in the Association Between Female Sex and Ischemic Stroke Among Patients With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- Association between cardiometabolic comorbidity and mortality in patients with atrial fibrillation.BMC cardiovascular disorders · 2025Observational
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Long-term outcomes of cryoballoon versus robotic magnetic navigation guided radiofrequency ablation in patients with persistent atrial fibrillation.Scientific reports · 2025Article
- Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020.World journal of cardiology · 2025Article
- Clinical Predictors of Warfarin Response Among Patients with Atrial Fibrillation: Evidence from the Middle Eastern JoFib Study.Current vascular pharmacology · 2025Observational
- Association between new-onset atrial fibrillation and adverse clinical outcomes by country of origin: A matched nationwide cohort study.Journal of migration and health · 2025Article
- Age-modified risk factors for mortality of non-elderly adult kidney transplant recipients: a retrospective database analysis.International urology and nephrology · 2024Article
- Article
- An anthropomorphic phantom for atrial transseptal puncture simulation training.3D printing in medicine · 2024Article
- Risk of stroke in male and female patients with atrial fibrillation in a nationwide cohort.Nature communications · 2024Article
- Social drivers in atrial fibrillation occurrence, screening, treatment, and outcomes: systematic-narrative hybrid review.European heart journal supplements : journal of the European Society of Cardiology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo assess temporal trends in the association between newly diagnosed atrial fibrillation and death.
designCommunity based cohort study.
settingFramingham Heart Study cohort, in 1972-85, 1986-2000, and 2001-15 (periods 1-3, respectively), in Framingham, MA, USA.
participantsParticipants with no atrial fibrillation, aged 45-95 in each time period, and identified with newly diagnosed atrial fibrillation (or atrial flutter) during each time period.
main outcome measuresThe main outcome was all cause mortality. Hazard ratios for the association between time varying atrial fibrillation and all cause mortality were calculated with adjustment for time varying confounding factors. The difference in restricted mean survival times, adjusted for confounders, between participants with atrial fibrillation and matched referents at 10 years after a diagnosis of atrial fibrillation was estimated. Meta-regression was used to test for linear trends in hazard ratios and restricted mean survival times over the different time periods.
results5671 participants were selected in time period 1, 6177 in period 2, and 6174 in period 3. Adjusted hazard ratios for all cause mortality between participants with and without atrial fibrillation were 1.9 (95% confidence interval 1.7 to 2.2) in time period 1, 1.4 (1.3 to 1.6) in period 2, and 1.7 (1.5 to 2.0) in period 3 (P
conclusionsNo evidence of a temporal trend in hazard ratios for the association between atrial fibrillation and all cause mortality was found. The mean number of life years lost to atrial fibrillation at 10 years had improved significantly, but a two year gap compared with individuals without atrial fibrillation still remained.
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