ArticleJournal of medical Internet research2020
Impact of a Multicomponent Digital Therapeutic Mobile App on Medication Adherence in Patients with Chronic Conditions: Retrospective Analysis.
Article in Journal of medical Internet research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Conceptual Ambiguity Surrounding Gamification and Serious Games in Health Care: Literature Review and Development of Game-Based Intervention Reporting Guidelines (GAMING).Journal of medical Internet research · 2021Pooled it
- The effect of reminder mobile application use on medication adherence after total thyroidectomy: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Effect of Gamification on Improved Adherence to Inhaled Medications in Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Enhancing tuberculosis treatment adherence and motivation through gamified real-time mobile app utilization: a single-arm intervention study.BMC public health · 2024Trial
- Evaluation of the effectiveness of the FOCUS ADHD App in monitoring adults with attention-deficit/hyperactivity disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023Trial
- Contexts and Mechanisms Related to the Efficacy of Digital Medication Adherence Interventions to Support Medication Adherence Among Adults With Chronic Diseases: Realist Review.Interactive journal of medical research · 2026Review
- Healthcare professionals' perspectives on medication adherence-supporting tools: a cross‑sectional survey in Italy.European journal of clinical pharmacology · 2026Article
- Blended Cognitive Behavioral Therapy versus Standard Cognitive Behavioral Therapy for Unipolar Depression: A Multicenter Randomized Controlled Trial.Psychotherapy and psychosomatics · 2026Article
- Mobile health apps for older adults: real-world evidence on engagement and medication adherence.Frontiers in digital health · 2026Article
- Validation of a novel patient-reported measure of the burden of digital care in diabetes.BMC medicine · 2025Article
- Digital Tools for Seizure Monitoring and Self-Management in Epilepsy: A Narrative Review.Journal of clinical medicine · 2025Review
- Study protocol: Apps and peer support for a healthy future and living well with diabetes (APHLID-M).Contemporary clinical trials communications · 2025Article
- Development and evaluation of an intelligent individualized nutrition management (iNutrition) applet for postdischarge gastric cancer patients following gastrectomy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Digital Medicine Tools and the Work of Being a Patient: A Qualitative Investigation of Digital Treatment Burden in Patients With Diabetes.Mayo Clinic proceedings. Digital health · 2025Article
- Intention to use mobile phone-based TB screening among HIV patients in Debre Tabor Town public health facilities, Northwest Ethiopia: a cross-sectional study.BMC public health · 2025Article
- An approach to boost adherence to self-data reporting in mHealth applications for users without specific health conditions.BMC medical informatics and decision making · 2025Article
- Development of the TBQ+D: A Novel Patient-Reported Measure of The Burden of Digital Care.Patient preference and adherence · 2025Article
- The Effectiveness of a Digital Mental Fitness Program (Positive Intelligence) on Perceived Stress, Self-Compassion, and Ruminative Thinking of Occupational Therapy Undergraduate Students: Longitudinal Study.Journal of medical Internet research · 2024Article
- The Use of Gamification in the Self-Management of Patients With Chronic Diseases: Scoping Review.JMIR serious games · 2023Article
- Digital therapeutics in the clinic.Bioengineering & translational medicine · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStrategies to improve medication adherence are widespread in the literature; however, their impact is limited in real practice. Few patients persistently engage long-term to improve health outcomes, even when they are aware of the consequences of poor adherence. Despite the potential of mobile phone apps as a tool to manage medication adherence, there is still limited evidence of the impact of these innovative interventions. Real-world evidence can assist in minimizing this evidence gap.
objectiveThe objective of this study was to analyze the impact over time of a previously implemented digital therapeutic mobile app on medication adherence rates in adults with any chronic condition.
methodsA retrospective observational study was performed to assess the adherence rates of patients with any chronic condition using Perx Health, a digital therapeutic that uses multiple components within a mobile health app to improve medication adherence. These components include gamification, dosage reminders, incentives, educational components, and social community components. Adherence was measured through mobile direct observation of therapy (MDOT) over 3-month and 6-month time periods. Implementation adherence, defined as the percentage of doses in which the correct dose of a medication was taken, was assessed across the study periods, in addition to timing adherence or percentage of doses taken at the appropriate time (±1 hour). The Friedman test was used to compare differences in adherence rates over time.
resultsWe analyzed 243 and 130 patients who used the app for 3 months and 6 months, respectively. The average age of the 243 patients was 43.8 years (SD 15.5), and 156 (64.2%) were female. The most common medications prescribed were varenicline, rosuvastatin, and cholecalciferol. The median implementation adherence was 96.6% (IQR 82.1%-100%) over 3 months and 96.8% (IQR 87.1%-100%) over 6 months. Nonsignificant differences in adherence rates over time were observed in the 6-month analysis (Fr(2)=4.314, P=.505) and 3-month analysis (Fr(2)=0.635, P=.728). Similarly, the timing adherence analysis revealed stable trends with no significant changes over time.
conclusionsRetrospective analysis of users of a medication adherence management mobile app revealed a positive trend in maintaining optimal medication adherence over time. Mobile technology utilizing gamification, dosage reminders, incentives, education, and social community interventions appears to be a promising strategy to manage medication adherence in real practice.
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