ArticleCell reports2020
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
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35 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Restoration of axon initial segment plasticity via chemogenetic activation rescues autism-related behaviors.Cell death & disease · 2026Article
- Mapping spatial organization of in vitro neuronal networks using high-content imaging.Scientific reports · 2025Article
- Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior.PLoS biology · 2025Article
- Higher hyperpolarization-activated current in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of fragile X mice.Journal of neurophysiology · 2025Article
- Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice.Neurobiology of disease · 2025Article
- Delayed onset of striatal projection neuron hyperexcitability inFrontiers in cellular neuroscience · 2025Article
- Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome.Frontiers in pharmacology · 2025Article
- Supra- and sub-threshold intracellular-like recording of 2D and 3D neuronal networks using nanopillar electrode arrays.Microsystems & nanoengineering · 2024Article
- Hypnotic treatment improves sleep architecture and EEG disruptions and rescues memory deficits in a mouse model of fragile X syndrome.Cell reports · 2024Article
- Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function.Translational psychiatry · 2024Article
- Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome.Brain sciences · 2023Article
- Current Best Practices for Analysis of Dendritic Spine Morphology and Number in Neurodevelopmental Disorder Research.ACS chemical neuroscience · 2023Review
- Review
- Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy.Translational vision science & technology · 2023Article
- Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion.BMC neuroscience · 2023Article
- Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome.Frontiers in cellular neuroscience · 2023Article
- Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome.Molecular autism · 2022Article
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Authors and funding
13 authors at 4 institutions in 3 countries.
Sam A BookerCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK. Electronic address: sbooker@ed.ac.uk.
Laura Simões de OliveiraCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK.
Natasha J AnsteyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India.
Zrinko KozicCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK.
Owen R DandoCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Dementia Research Institute, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India.
Adam D JacksonCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India.
Paul S BaxterCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Dementia Research Institute, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
Lori L IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109-5632, USA.
Diane L ShermanCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Giles E HardinghamCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Dementia Research Institute, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
Peter J BrophyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
David J A WyllieCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India.
Peter C KindCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK; Simons Initiative for the Developing Brain, University of Edinburgh, Edinburgh, UK; Patrick Wild Centre for Autism Research, University of Edinburgh, Edinburgh, UK; Centre for Brain Development and Repair, InStem, GKVK Campus, Bangalore 560065, India. Electronic address: pkind@ed.ac.uk.
Institute for Stem Cell Biology and Regenerative Medicine · INUniversity of Edinburgh · GBUK Dementia Research Institute · GBUniversity of Michigan · US
Funding
Role of SCN1B in Inherited EpilepsyR37NS076752 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 2017 to 2023
$4.8MMedical Research Council MR/P006213/1NINDS NIH HHS R37 NS076752
Abstract
Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment length in CA1 of the Fmr1
Indexed as
AnimalsDisease Models, AnimalFragile X SyndromeHomeostasisMicePyramidal Cells2-photon microscopyASD/IDaxon initial segmentfragile X syndromehippocampushomeostasishyperexcitabilityintrinsic excitabilitystructural plasticitywhole-cell patch clamp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.