ArticleCell2020
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
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In one paragraph
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 317 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
317citing papers in PubMed, 1 pooled it
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
317 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small Molecules.International journal of molecular sciences · 2022Pooled it
- Virologic insights from the phase 3 REDPINE trial: remdesivir in renally impaired and immunocompromised patients with COVID-19.Antimicrobial agents and chemotherapy · 2026Trial
- SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants.Antimicrobial agents and chemotherapy · 2025Trial
- Viral Resistance Analyses From the Remdesivir Phase 3 Adaptive COVID-19 Treatment Trial-1 (ACTT-1).The Journal of infectious diseases · 2023Trial
- Recent advances in functional studies of coronavirus NSP13 helicase and challenges in inhibitor development.Virulence · 2026Review
- MNS induces antiviral protection and suppresses inflammation.Annals of medicine · 2026Article
- The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism.The Journal of biological chemistry · 2026Article
- Molecular Docking of Natural Products: Critical Appraisal of Current Methodology and Practical Guidelines.Molecules (Basel, Switzerland) · 2026Review
- Hierarchical geometric deep learning enables scalable analysis of molecular dynamics.The Journal of chemical physics · 2026Article
- Repurposing drug screen for the identification of helicase inhibitors from viruses of pandemic concern.SLAS discovery : advancing life sciences R & D · 2026Article
- The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism.bioRxiv : the preprint server for biology · 2026Article
- Structure-Activity Relationships of Pyrrolyl-Containing Diketo Acid and Non-Diketo Acid Derivatives as Inhibitors of SARS-CoV-2 nsp13-Associated Activities.Molecules (Basel, Switzerland) · 2026Article
- Distinct RNA engagements define genome import and replication elongation in alphaviruses.bioRxiv : the preprint server for biology · 2026Article
- SARS-CoV-2 Nsp13 helicase resolves G-quadruplexes and is inhibited by G4 ligands or an antiviral regulator: Implications for G4 anti-coronavirus therapies.The Journal of biological chemistry · 2026Article
- Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir.Science advances · 2026Article
- Positive-Strand RNA Viral RdRps: From Structure Conservation and Activity Assay to Drug Development.Molecules (Basel, Switzerland) · 2026Review
- Targeting SARS-CoV-2 Non-Structural Proteins: A Blueprint for Next-Generation Small-Molecule Coronavirus Antivirals.Pharmaceutics · 2026Review
- Mechanochemical Decoupling of ATP Hydrolysis and RNA Translocation in SARS-CoV-2 nsp13 by the L405D Mutation.bioRxiv : the preprint server for biology · 2026Article
- RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA.Cell reports · 2026Article
- Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals.International journal of molecular sciences · 2026Article
257 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
James ChenLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Brandon MaloneLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Eliza LlewellynLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA.
Michael GrassoLaboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA.
Patrick M M SheltonLaboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA.
Paul Dominic B OlinaresLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.
Kashyap MaruthiThe National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.
Edward T EngThe National Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY 10027, USA.
Hasan VatandaslarInstitute of Molecular Health Sciences, ETH Zürich, 8093 Zürich, Switzerland.
Brian T ChaitLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA.
Tarun M KapoorLaboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA.
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA. Electronic address: darst@rockefeller.edu.
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA. Electronic address: campbee@rockefeller.edu.
Funding
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MNational Resource for Mass Spectrom of Biological MacromoleculesP41GM103314 · NIGMS · ROCKEFELLER UNIVERSITY · PI CHAIT, BRIAN T · 2012 to 2017
$9.9MStructure, function, and regulation of the bacterial transcription cycleR35GM118130 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2016 to 2025
$8.9MChemical Biology of Cell Division - Revision - 2R35GM130234 · NIGMS · ROCKEFELLER UNIVERSITY · PI TARUN M. KAPOOR · 2019 to 2026
$6.0MStructure, function, and inhibition of the SARS-CoV-2 replication-transcription complexR01AI161278 · NIAID · ROCKEFELLER UNIVERSITY · PI Seth A. Darst · 2021 to 2026
$3.9MStructure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4MNCRR NIH HHS P41 RR001209NIAID NIH HHS R01 AI161278NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM103314NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM114450NIGMS NIH HHS R35 GM118130NIGMS NIH HHS R35 GM130234NIGMS NIH HHS U24 GM129539
Abstract
SARS-CoV-2 is the causative agent of the 2019-2020 pandemic. The SARS-CoV-2 genome is replicated and transcribed by the RNA-dependent RNA polymerase holoenzyme (subunits nsp7/nsp8
Indexed as
Virus ReplicationAdenosine DiphosphateBetacoronavirusBinding SitesCoronavirus RNA-Dependent RNA PolymeraseCryoelectron MicroscopyHoloenzymesMagnesiumMethyltransferasesProtein BindingRNA-Dependent RNA PolymeraseRNA HelicasesRNA, ViralSARS-CoV-2Viral Nonstructural ProteinsAdenosine DiphosphateCoronavirus RNA-Dependent RNA PolymeraseHoloenzymesMagnesiumMethyltransferasesNS8 protein, SARS-CoV-2NSP12 protein, SARS-CoV-2Nsp13 protein, SARS-CoVORF1ab polyprotein, SARS-CoV-2RNA-Dependent RNA PolymeraseRNA HelicasesRNA, ViralViral Nonstructural Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.