Evidence map›Paper›PMID 32783690›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.

Thales C Barbosa, Benjamin E Young, Brandi Y Stephens, Damsara Nandadeva, Jasdeep Kaur, David M Keller, Paul J Fadel

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04770155 (Vascular Dysfunction in Black Individuals), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04770155 early_phase1terminatednot on this mapstarted 2021, after this paper: background citation

Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

TypeinterventionalSponsorUniversity of Mississippi Medical CenterRan2021 to 2021Enrolled8ConditionsVascular Function, Racial DisparityArmsDietary Nitrates 400 mg, L-citrulline 3 g, Sildenafil 100 mg, Bosentan 125 mg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thales C BarbosaDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0001-5776-3824
Benjamin E YoungDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0003-0239-005X
Brandi Y StephensDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0002-1624-8778
Damsara NandadevaDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Jasdeep KaurDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.ORCID 0000-0002-1264-6103
David M KellerDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Paul J FadelDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
The University of Texas at Arlington · US

Funding

Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel TherapiesR01HL127071 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI FADEL, PAUL J · 2016 to 2019
$1.7M
Sympathetic baroreflex control and vascular transduction in African AmericansR15HL130906 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI KELLER, DAVID M · 2016 to 2016
$377k
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL-127071HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL-130906NHLBI NIH HHS R01 HL127071NHLBI NIH HHS R15 HL130906
6 · The paper itself

Abstract

Black men have attenuated increases in forearm vascular conductance (FVC) and forearm blood flow (FBF) during moderate- and high-intensity rhythmic handgrip exercise compared with White men, but the underlying mechanisms are unclear. Here, we tested for the first time the hypothesis that functional sympatholysis (i.e., attenuation of sympathetic vasoconstriction in the exercising muscles) is impaired in Black men compared with White men. Thirteen White and 14 Black healthy young men were studied. FBF (duplex Doppler ultrasound) and mean arterial pressure (MAP; Finometer) were measured at rest and during rhythmic handgrip exercise at 30% maximal voluntary contraction. FVC was calculated as FBF/MAP. Sympathetic activation was induced via lower body negative pressure (LBNP) at -20 Torr for 2 min at rest and from the 3rd to the 5th min of handgrip. Sympathetic vasoconstriction was assessed as percent reductions in FVC during LBNP. The groups presented similar resting FVC, FBF, and MAP. During LBNP at rest, reductions in FVC were not different between White (-35 ± 10%) and Black men (-32 ± 14%,

Indexed as

AdultExerciseHand StrengthHumansMaleMuscle ContractionMuscle, SkeletalOxygen ConsumptionRegional Blood FlowSympathetic Nervous SystemVasoconstrictionAfrican AmericanCaucasian Americandynamic exerciseethnicitymuscle hyperemia

Identifiers

PMID32783690
PMCPMC7509252
OpenAlexW3048447919

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.