Evidence map›Paper›PMID 32783661›Full record

ArticleDNA and cell biology2020

Systematic Analysis of Autophagy-Related Signature Uncovers Prognostic Predictor for Acute Myeloid Leukemia.

Xue-Xing Chen, Zi-Ping Li, Jian-Hua Zhu, Hai-Tao Xia, Hao Zhou

Open access · greenAbstract read
In one paragraph

Article in DNA and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Frontiers in oncology · 2026
    Article
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  5. Review
  6. A novel prognostic model of methylation-associated genes in acute myeloid leukemia.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  7. Autophagy and Its Lineage-Specific Roles in the Hematopoietic System.Oxidative medicine and cellular longevity · 2023
    Review
  8. The dual role of autophagy in acute myeloid leukemia.Journal of hematology & oncology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Article
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  19. Identification ofJournal of oncology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xue-Xing ChenInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zi-Ping LiInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jian-Hua ZhuLaboratory of Clinical Immunology, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hai-Tao XiaDepartment of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hao ZhouInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNUnion Hospital · CNWuhan No.1 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy, a highly conserved cellular protein degradation process, has been involved in acute myeloid leukemia (AML). The present study aims to establish a novel, autophagy-related prognostic signature for prediction of AML prognosis. Differentially expressed autophagy-related genes in AML and healthy samples were screened using GSE1159. Univariate Cox regression analysis was applied to determine survival-associated autophagy-related genes in The Cancer Genome Atlas (TCGA) AML cohort. Lasso regression was performed to develop multiple-gene prognostic signatures. A novel six-gene signature (including

Indexed as

AutophagyTranscriptomeBiomarkers, TumorCaspase 3Cell Cycle ProteinsChromatin Assembly Factor-1Endosomal Sorting Complexes Required for TransportHumansLeukemia, Myeloid, AcuteMembrane Transport ProteinsRepressor ProteinsVascular Endothelial Growth Factor ABiomarkers, TumorCASP3 protein, humanCaspase 3Cell Cycle ProteinsCHAF1B protein, humanChromatin Assembly Factor-1Endosomal Sorting Complexes Required for TransportKLHL24 protein, humanMembrane Transport ProteinsOPTN protein, humanRepressor ProteinsVascular Endothelial Growth Factor AVEGFA protein, humanVPS37C protein, humanacute myeloid leukemiaautophagyprognosissignature

Identifiers

PMID32783661
PMCPMC7482110
OpenAlexW3048397779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.