Evidence map›Paper›PMID 32783388›Full record

ReviewMedicinal research reviews2021

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy.

Kundlik Gadhave, Deepak Kumar, Vladimir N Uversky, Rajanish Giri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medicinal research reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. The Hallmarks of Ageing in Microglia.Cellular and molecular neurobiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kundlik GadhaveSchool of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.ORCID 0000-0003-4530-4772
Deepak KumarSchool of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.
Vladimir N UverskyDepartment of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-4037-5857
Rajanish GiriSchool of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.

Funding

Controlling tau toxicity from inside and outside of neuronsRF1AG055088 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI BICKFORD, PAULA C, BLAIR, LAURA J · 2017 to 2017
$2.3M
NIA NIH HHS RF1 AG055088
6 · The paper itself

Abstract

The exact molecular mechanisms associated with Alzheimer's disease (AD) pathology continue to represent a mystery. In the past decades, comprehensive data were generated on the involvement of different signaling pathways in the AD pathogenesis. However, the utilization of signaling pathways as potential targets for the development of drugs against AD is rather limited due to the immense complexity of the brain and intricate molecular links between these pathways. Therefore, finding a correlation and cross-talk between these signaling pathways and establishing different therapeutic targets within and between those pathways are needed for better understanding of the biological events responsible for the AD-related neurodegeneration. For example, autophagy is a conservative cellular process that shows link with many other AD-related pathways and is crucial for maintenance of the correct cellular balance by degrading AD-associated pathogenic proteins. Considering the central role of autophagy in AD and its interplay with many other pathways, the finest therapeutic strategy to fight against AD is the use of autophagy as a target. As an essential step in this direction, this comprehensive review represents recent findings on the individual AD-related signaling pathways, describes key features of these pathways and their cross-talk with autophagy, represents current drug development, and introduces some of the multitarget beneficial approaches and strategies for the therapeutic intervention of AD.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAutophagyBrainHumansSignal TransductionAmyloid beta-PeptidesAlzheimer's diesaseamyloid βautophagyneurofibrillary tanglesenile plaquesignaling pathwaystau

Identifiers

PMID32783388
PMCPMC7876169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.