ReviewAddiction biology2022
Closing the brain-heart loop: Towards more holistic models of addiction and addiction recovery.
Review in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- One-stop shopping for recovery? A systematic review of the evidence on U.S. recovery community centers.Journal of substance use and addiction treatment · 2025Pooled it
- Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial.JAMA psychiatry · 2025Trial
- Changes in interoception after alcohol administration correlate with expectancies and subjective effects.Addiction biology · 2022Trial
- An interoceptive basis for alcohol priming effects.Psychopharmacology · 2021Trial
- Directional Brain Connectivity Changes Induced by Heart Rate Variability Biofeedback: A Spectral Dynamic Causal Modeling Study.Research square · 2026Article
- Temporal dynamic brain-heart interaction alterations associated with suicidal ideation in major depressive disorder.BMC psychiatry · 2026Article
- Development of a Heart Rate Variability Based Ambulatory Stress Detection Model for Clinical Populations.Applied psychophysiology and biofeedback · 2026Article
- Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment.Frontiers in psychiatry · 2026Article
- Reciprocal brain-behavior associations in gambling disorder revealed by theta cordance and directional predictive modeling.Frontiers in behavioral neuroscience · 2026Article
- Externalizing as a common genetic influence for a broad spectrum of substance use and behavioral conditions: A developmental perspective from the Avon Longitudinal Study of Parents and Children.Addiction (Abingdon, England) · 2025Article
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Review
- Time Since Last Drink is Positively Associated with Heart Rate Variability in Outpatients with Alcohol Use Disorder: Further Evidence of Psychophysiological Recovery in Early Alcohol Use Disorder Recovery.Applied psychophysiology and biofeedback · 2023Article
- Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review.Neuroscience and biobehavioral reviews · 2023Article
- In natura heart rate variability predicts subsequent alcohol use in individuals in early recovery from alcohol use disorder.Addiction biology · 2023Article
- Article
- Experimental Investigation of the Influence of Positive Emotion Dysregulation on Risky Behavior Following Idiographic Emotion Inductions.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder.Drug and alcohol dependence · 2023Article
- Editorial: Integrated cardiovascular and neural system processes as potential mechanisms of behavior change.Frontiers in psychiatry · 2023Article
- The Process of Heart Rate Variability, Resonance at 0.1 hz, and the Three Baroreflex Loops: A Tribute to Evgeny Vaschillo.Applied psychophysiology and biofeedback · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Much research seeks to articulate the brain structures and pathways implicated in addiction and addiction recovery. Prominent neurobiological models emphasize the interplay between cortical and limbic brain regions as a main driver of addictive processes, but largely do not take into consideration sensory and visceral information streams that link context and state to the brain and behavior. Yet these brain-body information streams would seem to be necessary elements of a comprehensive model of addiction. As a starting point, we describe the overlap between one current model of addiction circuitry and the neural network that not only regulates cardiovascular system activity but also receives feedback from peripheral cardiovascular processes through the baroreflex loop. We highlight the need for neurobiological, molecular, and behavioral studies of neural and peripheral cardiovascular signal integration during the experience of internal states and environmental contexts that drive alcohol and other drug use behaviors. We end with a call for systematic, mechanistic research on the promising, yet largely unexamined benefits to addiction treatment of neuroscience-informed, adjunctive interventions that target the malleability of the cardiovascular system to alter brain processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.