Evidence map›Paper›PMID 32783200›Full record

ArticleMagnetic resonance in medicine2021

Design and evaluation of quantitative MRI phantoms to mimic the simultaneous presence of fat, iron, and fibrosis in the liver.

Ruiyang Zhao, Gavin Hamilton, Jean H Brittain, Scott B Reeder, Diego Hernando

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Impact of particle size onMagnetic resonance in medicine · 2025
    Article
  9. Improved liver fat andMagnetic resonance in medicine · 2025
    Article
  10. Effect of particle size on liver MRIMagnetic resonance in medicine · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. RSC advances · 2022
    Article
  15. Evaluation of Hepatic Iron Overload Using a Contemporary 0.55 T MRI System.Journal of magnetic resonance imaging : JMRI · 2022
    Article
  16. Review
  17. Limits of Fat Quantification in the Presence of Iron Overload.Journal of magnetic resonance imaging : JMRI · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruiyang ZhaoDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-2386-9767
Gavin HamiltonDepartment of Radiology, University of California-San Diego, San Diego, California, USA.
Jean H BrittainDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Scott B ReederDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4728-8171
Diego HernandoDepartment of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-0016-0317
University of Wisconsin–Madison · USUniversity of California San Diego · US

Funding

Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017
$2.7M
MRI-based Quantitative Susceptibility Mapping of Hepatic Iron OverloadR01DK117354 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2018 to 2021
$2.3M
Quantitative Magnetic Resonance Imaging PhantomsR44EB025729 · NIBIB · CALIMETRIX, LLC · PI BRITTAIN, JEAN H., HERNANDO, DIEGO · 2019 to 2020
$1.5M
Technical Development of Quantitative Biomarkers of Fatty Liver Disease with MRIR01DK083380 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2010 to 2013
$1.2M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
Quantitative Magnetic Resonance Imaging PhantomsR41EB025729 · NIBIB · CALIMETRIX, LLC · PI HERNANDO, DIEGO · 2018 to 2018
$239k
NIBIB NIH HHS R41 EB025729NIBIB NIH HHS R44 EB025729NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK083380NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R01 DK100651NIDDK NIH HHS R01 DK117354
6 · The paper itself

Abstract

purposeTo design, construct, and evaluate quantitative MR phantoms that mimic MRI signals from the liver with simultaneous control of three parameters: proton-density fat fraction (PDFF),

methodsPhantoms including multiple vials were constructed. Peanut oil was used to modulate PDFF, MnCl

resultsHigh-quality PDFF and

conclusionNovel quantitative MRI phantoms that mimic the simultaneous presence of fat, iron, and fibrosis in the liver were successfully developed and validated.

Indexed as

IronMagnetic Resonance ImagingFibrosisHumansLiverReproducibility of ResultsIronliverphantomproton-density fat fractionquantitative imaging biomarkersT1

Identifiers

PMID32783200
PMCPMC7722215
OpenAlexW3048705637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.