Evidence map›Paper›PMID 32783110›Full record

ReviewHeart failure reviews2021

Bias in natriuretic peptide-guided heart failure trials: time to improve guideline adherence using alternative approaches.

Susan Stienen, Ankeet Bhatt, João Pedro Ferreira, Muthiah Vaduganathan, James Januzzi, Kirkwood Adams, Jean-Claude Tardif, Patrick Rossignol, Faiez Zannad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susan StienenINSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM U1116, Université de Lorraine, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Nancy, France. s.stienen@amc.uva.nl.ORCID 0000-0002-5573-9377
Ankeet BhattBrigham and Women's Hospital, Boston, MA, USA.
João Pedro FerreiraINSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM U1116, Université de Lorraine, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Nancy, France.
Muthiah VaduganathanBrigham and Women's Hospital, Boston, MA, USA.
James JanuzziMassachusetts General Hospital, Boston, MA, USA.
Kirkwood AdamsUniversity of North Carolina, Chapel Hill, NC, USA.
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, Montréal, Canada.
Patrick RossignolINSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM U1116, Université de Lorraine, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Nancy, France.
Faiez ZannadINSERM, Centre d'Investigations Cliniques Plurithématique 1433, INSERM U1116, Université de Lorraine, CHRU de Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Université de Lorraine, Nancy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline adherence and uptitration, several trials have investigated a biomarker-guided strategy (using natriuretic peptide targets in specific), but although conceptually promising, these trials failed to show a consistent beneficial effect on outcomes. In this review, we discuss different methodological issues that may explain the failure of these trials and offer potential solutions. Moreover, alternative approaches to increase heart failure guideline adherence are evaluated.

Indexed as

Heart FailureVentricular Dysfunction, LeftGuideline AdherenceHumansNatriuretic Peptide, BrainNatriuretic PeptidesStroke VolumeNatriuretic Peptide, BrainNatriuretic PeptidesAdherenceBiasBiomarkerBiomarker-guided trialsGuideline-directedHFrEFMedical therapyNatriuretic peptides

Identifiers

PMID32783110
PMCPMC7769782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.