Evidence map›Paper›PMID 32782986›Full record

ArticleInternational journal of bioprinting2020

Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation.

Cijun Shuai, Yang Li, Wenjing Yang, Li Yu, Youwen Yang, Shuping Peng, Pei Feng

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Selective Laser Sintering of Polydimethylsiloxane Composites.3D printing and additive manufacturing · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Electrostatic self-assembly ofJournal of advanced research · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Cijun ShuaiState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Yang LiState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Wenjing YangState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Li YuState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Youwen YangInstitute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China.
Shuping PengNHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan China.
Pei FengState Key Laboratory of High-Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Central South University · CNState Key Laboratory of High Performance Complex ManufacturingJiangxi University of Science and Technology · CNShenzhen Institute of Information Technology · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.

Indexed as

Degradation propertyEster bonds hydrolysisGOPoly-l-lactic acid scaffold

Identifiers

PMID32782986
PMCPMC7415862
OpenAlexW3000945680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.