Evidence map›Paper›PMID 32782983›Full record

ArticleInternational journal of bioprinting2020

Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity.

Rodica Cristescu, Irina Negut, Anita Ioana Visan, Alexander K Nguyen, Andrew Sachan, Peter L Goering, Douglas B Chrisey, Roger J Narayan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Rodica CristescuDepartment of Lasers, National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, Bucharest-Magurele, Romania.
Irina NegutDepartment of Lasers, National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, Bucharest-Magurele, Romania.
Anita Ioana VisanDepartment of Lasers, National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, Bucharest-Magurele, Romania.
Alexander K NguyenUNC/NCSU Joint Department of Biomedical Engineering, Raleigh, North Carolina, USA.
Andrew SachanWake Technical Community College, Raleigh, North Carolina, USA.
Peter L GoeringCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Douglas B ChriseyDepartment of Physics and Engineering Physics, Tulane University, New Orleans, LA, USA.
Roger J NarayanUNC/NCSU Joint Department of Biomedical Engineering, Raleigh, North Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix-assisted pulsed laser evaporation (MAPLE) has many benefits over conventional methods (e.g., dip-coating, spin coating, and Langmuir-Blodgett dip-coating) for manufacturing coatings containing pharmacologic agents on medical devices. In particular, the thickness of the coating that is applied to the surface of the medical device can be tightly controlled. In this study, MAPLE was used to deposit rapamycin-polyvinylpyrrolidone (rapamycin-PVP) thin films onto silicon and borosilicate optical glass substrates. Alamar Blue and PicoGreen studies were used to measure the metabolic health and DNA content of L929 mouse fibroblasts as measures of viability and proliferation, respectively. The cells on the MAPLE-deposited rapamycin-PVP surfaces exhibited 70.6% viability and 53.7% proliferation compared to a borosilicate glass control. These data indicate that the antiproliferative properties of rapamycin were maintained after MAPLE deposition.

Indexed as

Drug deliveryMatrix-assisted pulsed laser evaporationRapamycinThin film

Identifiers

PMID32782983
PMCPMC7415860

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.