ArticleJGH open : an open access journal of gastroenterology and hepatology2020
Repertoire analysis of memory T-cell receptors in Japanese patients with inflammatory bowel disease.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.JCI insight · 2026Article
- Clonal overlap and convergent clustering of T cell receptor signatures in Crohn's disease in monozygotic twins.Inflammatory bowel diseases · 2026Article
- Single-cell analysis reveals islet autoantigen's immune activation in type 1 diabetes patients.Journal of clinical biochemistry and nutrition · 2025Article
- Reduced diversity of intestinal T-cell receptor repertoire in patients with Crohn's disease.Frontiers in cellular and infection microbiology · 2022Article
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Authors and funding
16 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
aimThe T-cell receptor (TCR) repertoire was assessed in response to various antigens and was considered to be associated with the pathogenesis of inflammatory bowel disease (IBD). Thus, we performed TCR repertoire analysis to examine the pathology of IBD from changes in the TCR repertoire of memory T cells in the intestinal lamina propria mononuclear cells (LPMCs) and peripheral blood mononuclear cells (PBMCs) of patients with IBD.
methodsLPMCs in the surgical specimens and PBMCs were isolated from 12 patients with IBD (5 patients with ulcerative colitis [UC] and 7 patients with Crohn's disease [CD]). PBMCs were collected from 10 healthy individuals as controls. Comprehensive TCR sequence analyses of adaptor-ligation polymerase chain reaction (PCR) products were performed using MiSeq.
resultsThe diversity of TCR-α and TCR-β in PBMCs was significantly lower in patients with IBD than that in controls (
conclusionThe diversity of TCR clones in LPMCs and PBMCs in patients with IBD was significantly lower than that of PBMCs in controls. TCR diversity in PBMCs was particularly low in patients with CD.
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