Evidence map›Paper›PMID 32782827›Full record

ArticleCardio-oncology (London, England)2020

Atlas-based measures of left ventricular shape may improve characterization of adverse remodeling in anthracycline-exposed childhood cancer survivors: a cross-sectional imaging study.

Hari K Narayan, Ronghui Xu, Nickolas Forsch, Sachin Govil, David Iukuridze, Lanie Lindenfeld, Eric Adler, Sanjeet Hegde, Adriana Tremoulet, Bonnie Ky and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. A deep learning approach for fully automated cardiac shape modeling in tetralogy of Fallot.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hari K NarayanDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive #0831, La Jolla, CA 92093-0831 USA.
Ronghui XuDepartment of Family Medicine and Public Health, University of California San Diego, 9500 Gilman Drive #0628, La Jolla, CA 92093-0628 USA.
Nickolas ForschDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive #0412, La Jolla, CA 92093-0412 USA.
Sachin GovilDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive #0412, La Jolla, CA 92093-0412 USA.
David IukuridzeDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive #0831, La Jolla, CA 92093-0831 USA.
Lanie LindenfeldDepartment of Population Sciences, City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010 USA.
Eric AdlerDepartment of Medicine, University of California San Diego, 9500 Gilman Drive #8811, La Jolla, CA 92093-8811 USA.
Sanjeet HegdeDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive #0831, La Jolla, CA 92093-0831 USA.
Adriana TremouletDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive #0831, La Jolla, CA 92093-0831 USA.
Bonnie KyDepartment of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 USA.
Saro ArmenianDepartment of Population Sciences, City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010 USA.
Jeffrey OmensDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive #0412, La Jolla, CA 92093-0412 USA.
Andrew D McCullochDepartment of Bioengineering, University of California San Diego, 9500 Gilman Drive #0412, La Jolla, CA 92093-0412 USA.
University of California, San Diego · USCity of Hope · USUniversity of Pennsylvania · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
The Cardiac Atlas ProjectR01HL121754 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D., OMENS, JEFFREY H. · 2014 to 2023
$5.0M
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS R01 HL121754
6 · The paper itself

Abstract

backgroundAdverse cardiac remodeling is an important precursor to anthracycline-related cardiac dysfunction, however conventional remodeling indices are limited. We sought to examine the utility of statistical atlas-derived measures of ventricular shape to improve the identification of adverse anthracycline-related remodeling in childhood cancer survivors.

methodsWe analyzed cardiac magnetic resonance imaging from a cross-sectional cohort of 20 childhood cancer survivors who were treated with low (< 250 mg/m

resultsCompared with the reference population, survivors had differences in conventional measures (lower volume and mass) and shape modes (corresponding to lower overall size and lower sphericity; all

conclusionsCompared with a reference population, heart size is smaller in anthracycline-exposed childhood cancer survivors. Atlas-based measures of left ventricular shape may improve the detection of anthracycline dose-related remodeling differences.

Indexed as

Anthracycline cardiotoxicityCardiac magnetic resonance imagingCardio-oncologyChildhood cancerStatistical shape atlas

Identifiers

PMID32782827
PMCPMC7414730
OpenAlexW3047987002

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.