Evidence map›Paper›PMID 32782796›Full record

ArticleSAGE open medicine2020

Persistence of oncogenic and non-oncogenic human papillomavirus is associated with human immunodeficiency virus infection in Kenyan women.

Yan Tong, Philip Tonui, Aaron Ermel, Omenge Orang'o, Nelson Wong, Maina Titus, Stephen Kiptoo, Kapten Muthoka, Patrick J Loehrer, Darron R Brown

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yan TongIndiana University School of Medicine, Indianapolis, IN, USA.
Philip TonuiMoi University, Eldoret, Kenya.
Aaron ErmelIndiana University School of Medicine, Indianapolis, IN, USA.
Omenge Orang'oMoi University, Eldoret, Kenya.
Nelson WongIndiana University School of Medicine, Indianapolis, IN, USA.
Maina TitusMaseno University, Maseno, Kenya.
Stephen KiptooMoi University, Eldoret, Kenya.
Kapten MuthokaMoi University, Eldoret, Kenya.
Patrick J LoehrerIndiana University School of Medicine, Indianapolis, IN, USA.
Darron R BrownIndiana University School of Medicine, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0001-5887-4382
Indiana University School of MedicineMoi University · KEMaseno University · KE

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Translational Biology CoreU54CA190151 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROWN, DARRON R, LOEHRER, PATRICK J. · 2014 to 2019
$3.8M
Brown/Moi Training Program for the Prevention of HIV related Cervical CancerD43TW011317 · FIC · BROWN UNIVERSITY · PI CU-UVIN, SUSAN · 2019 to 2023
$1.6M
FIC NIH HHS D43 TW011317NCI NIH HHS P30 CA082709NCI NIH HHS U54 CA190151NIAID NIH HHS P30 AI042853
6 · The paper itself

Abstract

objectivesCervical cancer is caused by persistent infection with oncogenic, or "high-risk" types of human papillomaviruses, and is the most common malignancy in Kenyan women. A longitudinal study was initiated to investigate factors associated with persistent human papillomavirus detection among HIV-infected and HIV-uninfected Kenyan women without evidence of cervical dysplasia.

methodsDemographic/behavioral data and cervical swabs were collected from HIV-uninfected women (n = 82) and HIV-infected women (n = 101) at enrollment and annually for 2 years. Human papillomavirus typing was performed on swabs (Roche Linear Array). Logistic regression models of human papillomavirus persistence were adjusted for demographic and behavioral characteristics.

resultsHIV-infected women were older and less likely to be married and to own a home and had more lifetime sexual partners than HIV-uninfected women. All HIV-infected women were receiving anti-retroviral therapy at enrollment and had satisfactory CD4 cell counts and HIV viral loads. One- and two-year persistent human papillomavirus detection was significantly associated with HIV infection for any human papillomavirus, high-risk human papillomavirus, International Agency for the Research on Cancer-classified high-risk human papillomavirus, and non-oncogenic "low-risk" human papillomavirus.

conclusionPersistent detection of oncogenic and non-oncogenic human papillomavirus was strongly associated with HIV infection in Kenyan women with re-constituted immune systems based on satisfactory CD4 cell counts. In addition to HIV infection, factors associated with an increased risk of human papillomavirus persistence included a higher number of lifetime sex partners. Factors associated with decreased risk of human papillomavirus persistence included older age and being married. Further studies are needed to identify the immunological defects in HIV-infected women that allow human papillomavirus persistence, even in women receiving effective anti-retroviral therapy. Further studies are also needed to determine the significance of low-risk human papillomavirus persistence in HIV-infected women.

Indexed as

Infectious diseasesoncologywomen’s health

Identifiers

PMID32782796
PMCPMC7388102
OpenAlexW3046037427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.