ArticleInternational journal of clinical and experimental pathology2020
Clinical and molecular characteristics of secondary breast metastases from primary lung cancer: a study of 22 Chinese cases.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- A Rare Case of Small Cell Lung Carcinoma Diagnosed with a Breast Mass.Molecular imaging and radionuclide therapy · 2026Article
- Breast Mass Revealing Hidden Lung Cancer.Cureus · 2025Article
- The rare case of synchronous bilateral breast metastasis from a lung neuroendocrine tumor (small cell lung carcinoma): a case report and literature review.Surgical case reports · 2024Article
- Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features.Translational lung cancer research · 2021Article
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Authors and funding
6 authors.
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Abstract
backgroundTo analyze the clinical and molecular characteristics, as well as pathologic diagnosis and treatment of lung tumors that spread to the breast in 22 Chinese patients. MATERIALS AND
methodsA systematic literature search of PubMed, Embase, ScienceDirect, Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database and Wanfang Databases was conducted to identify the related studies published before March 31, 2020. A case of a 64-year-old man who underwent pneumonectomy and who was eventually diagnosed with a breast lump 5 years after surgery at our hospital, was also included in the present study. We analyzed the clinical and immunohistochemical characteristics from these case reports.
resultsThe analysis totally incorporates 21 case reports and our own case, covering 22 subjects. Among all cases we found 11 adenocarcinomas, 7 small-cell carcinomas, and 4 squamous carcinomas. In addition, most of metastatic breast masses were located below or near the nipple, rather than in the outer quadrant. The results of immunohistochemistry mostly showed triple negative breast cancers.
conclusionA lung cancer patient with a breast tumor should suggest the possibility of metastasis. It is extremely difficult to distinguish secondary breast cancer from primary simply through medical observation and pathologic testing. Additional immunohistochemical examinations are necessary to avoid delays in diagnosis and treatment.
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