ArticleInternational journal of clinical and experimental pathology2020
Correlation among different pathologic features of renal cell carcinoma: a retrospective analysis of 249 cases.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- Oncologic outcomes and prognostic significance of lymphovascular invasion in renal cell carcinoma according to nodal stage.International urology and nephrology · 2026Article
- Predicting Carotid Body Tumors' Hardness via Multimodal Imaging: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- DNA Polymerase Delta 1 Catalytic Subunit (POLD1) as a Prognostic Factor in Clear Cell Renal Cell Carcinoma Patients.In vivo (Athens, Greece)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Renal cell carcinoma (RCC) represents 90% of renal malignancies and is the most lethal neoplasm of the urologic system. RCC is not a single entity but rather a heterogeneous group of neoplasms with varying genetic, morphologic and clinical features and outcome. The aim of this study was to correlate pathologic features of RCC that can be helpful during the decision-making process. We present a retrospective analysis of 249 RCCs (203 clear cell, 32 papillary and 14 chromophobe RCCs). We found that 77.8% of tumors of ≤4 cm and only 28.8% of RCC of >7 cm were limited to the kidney. The likelihood of lymphovascular invasion, fibrous renal capsule/perinephric fat/renal sinus fat, and vascular infiltration increased dramatically with increasing tumor size, particularly over 4.5 cm. Fat tissue was more often invaded through the renal sinus than through the renal capsule. Nuclear grade was significantly related to the pT stage, tumor size, percentage of necrotic area, lymphovascular invasion, fibrous renal capsule/perinephric fat/renal sinus fat and vascular infiltration. Tumor size represents one of the most important factors determining biological behavior of renal cancer. Renal sinus and perinephric fat should be carefully investigated, particularly in case of tumors >4-5 cm. Despite increasing acceptance for partial nephrectomy in tumors >7 cm, these cancers invade renal sinus fat 11 times more often and perinephric fat 5.6 times more often than smaller ones.
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32782695PMC7414505W3049110012What OpenQuestion holds
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