ArticleInternational journal of clinical and experimental pathology2020
Influence of dl-3-N-butylphthalide on infarction size in rats with acute myocardial infarction.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats.Journal of thoracic disease · 2022Article
- The effect and mechanism of dl-3-n-butylphthalide on angiogenesis in a rat model of chronic myocardial ischemia.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the influence of dl-3-N-butylphthalide (NBP) on infarction size in rats with acute myocardial infarction (AMI).
methodsAMI model was established by ligation of the left anterior descending artery. A total of 36 healthy male Sprague-Dawley rats (weight, 180 t, 180 ght, 180 ligation of left anterior descending artery. A total of 36 healthy males were assigned to model group, sham-operation (SO) group, and the NBP group (n=12 each). The rats in the NBP group were treated with intraperitoneal injection administration of 60 mg/kg/body weight NBP once a day. The rats in the other groups were given distilled water of the same volume. The MI area in each group was detected by TTC staining. The concentrations of CK-MB and LDH were detected. The concentrations of TNF-α, IL-6, MDA, and SOD were measured by ELISA.
resultsCompared with the SO group, the myocardial infarct sizes in the model group and the NBP group were significantly increased (
conclusionNBP can reduce the infarct size in SD rats with AMI.
Indexed as
Identifiers
32782693PMC7414500W3049730132What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.