ArticleInternational journal of clinical and experimental pathology2020
Prognostic values of CEA, CA19-9, and CA72-4 in patients with stages I-III colorectal cancer.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- A novel nutritional immune risk score model for long-term prognosis in colorectal cancer using clustering and principal component analysis.Frontiers in nutrition · 2026Article
- Identification and Validation of Biomarkers to Predict Early Diagnosis of Inflammatory Bowel Disease and Its Progression to Colorectal Cancer.Biochemical genetics · 2025Article
- Conditional survival and the prognostic value of serum carcinoembryonic antigen level in oldest old with colorectal cancer.BMC gastroenterology · 2024Article
- (Sialyl)Lewis Antigen Expression on Glycosphingolipids, N-, and O-Glycans in Colorectal Cancer Cell Lines is Linked to a Colon-Like Differentiation Program.Molecular & cellular proteomics : MCP · 2024Article
- Preoperative CA 19-9 Predicts Disease Progression in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: An Analysis from the US HIPEC Collaborative.Annals of surgical oncology · 2024Article
- Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer.Pathology oncology research : POR · 2024Article
- Thymosin α1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery.Open life sciences · 2024Article
- In-Depth Analysis of theInternational journal of molecular sciences · 2023Article
- A Novel ssDNA Aptamer Targeting Carcinoembryonic Antigen: Selection and Characterization.Biology · 2022Article
- Clinical Significance of Early Carcinoembryonic Antigen Change in Patients With Nonmetastatic Colorectal Cancer.Frontiers in oncology · 2022Article
- Elevated CEA and CA 19-9 Levels within the Normal Ranges Increase the Likelihood of CRC Recurrence in the Chinese Han Population.Applied bionics and biomechanics · 2022Article
- The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer.Frontiers in endocrinology · 2022Review
- Profiling Colorectal Cancer in the Landscape Personalized Testing-Advantages of Liquid Biopsy.International journal of molecular sciences · 2021Review
- A New Oxaliplatin Resistance-Related Gene Signature With Strong Predicting Ability in Colon Cancer Identified by Comprehensive Profiling.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to explore the relationship between the levels of three tumor markers (TMs), carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, and CA72-4, and the prognoses of colorectal cancer patients.
methodsFrom January 2012 to December 2015, 101 patients with stages I-III colorectal cancer treated in the general surgery department of Nanfang Hospital, Southern Medical University were included in this retrospective study. The patients' blood was collected at different time points to determine their biochemical index values. The CA19-9 and CEA levels were measured using a chemiluminescence analyzer, and the CA72-4 level was determined using a semi-automatic enzyme-free analyzer. The relationship between the tumor marker expressions and the prognoses of patients with colorectal cancer was analyzed.
resultsThe sensitivity of the combined quantification of the three TMs was higher than quantifying just one of them, but the specificity was decreased. Those three TM levels were stable at two years after the operations, and they were significantly lower than they were before the operations (P < 0.05). A Kaplan Meier survival curve analysis showed that, compared with the patients with normal levels, the patients with increased levels of the three TMs had significantly shorter overall survival times and higher recurrence rates (P < 0.05).
conclusionThe combined quantification of CEA, CA19-9, and CA72-4 is of great significance in determining the prognoses of colorectal cancer patients. It is helpful to predict the outcomes of patients with stages I-III colorectal cancer two years after their operations.
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32782679PMC7414469W3049710522What OpenQuestion holds
Registered trials
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