ArticleInternational journal of clinical and experimental pathology2020
Expression of TAZ, YAP, and β-catenin in cervical squamous cell carcinoma and their clinical significance.
Article in International journal of clinical and experimental pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.Apoptosis : an international journal on programmed cell death · 2024Article
- Never in mitosis gene A-related kinase-8 promotes proliferation, migration, invasion, and stemness of breast cancer cells via β-catenin signalling activation.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
YAP/TAZ and β-catenin are important effectors in the Hippo and Wnt signaling pathways, respectively, which are involved in the development of human tumors. Using immunohistochemistry, the expression levels of the three proteins were determined in 151 cervical tissue samples (including 28 normal cervical, 31 cervical intraepithelial neoplasia, and 92 cervical squamous cell carcinoma [CSC] tissues), which were excised or biopsied by surgery. The results showed that the three proteins were differently expressed in normal, precancerous, and CSC tissues, and β-catenin expression positively correlated with both YAP and TAZ expression. By analyzing the relationships between YAP, TAZ, and β-catenin expression and the clinicopathologic characteristics of patients with CSC, we found that YAP was related to the depth of invasion > 1/2, the diameter of the tumor > 4 cm, and positive lymph nodes; while TAZ and β-catenin were related to the depth of invasion > 1/2 and positive lymph nodes. Regarding the prognostic factors of patients with CSC, Kaplan-Meier univariate and Cox multivariate regression analysis showed that there were significant correlations between lymph node infiltration; expression of YAP, TAZ, and β-catenin; and patient mortality (P < 0.05), all of which were independent factors influencing mortality (OR > 1).
Indexed as
Identifiers
32782674PMC7414462W3049309905What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.