Evidence map›Paper›PMID 32782546›Full record

ArticleOncology letters2020

Mechanistic studies of cytotoxic activity of the mesoionic compound MIH 2.4Bl in MCF-7 breast cancer cells.

Luciana Amaral de Mascena Costa, Dipti Debnath, Ashlyn C Harmon, Silvany de Sousa Araújo, Helivaldo Diógenes da Silva Souza, Petrônio Filgueiras de Athayde Filho, Aurea Wischral, Manoel Adrião Gomes Filho, J Michael Mathis

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Luciana Amaral de Mascena CostaDepartment of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil.
Dipti DebnathGraduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Ashlyn C HarmonDepartment of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Silvany de Sousa AraújoDepartment of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil.
Helivaldo Diógenes da Silva SouzaDepartment of Chemistry, Federal University of Paraíba, Cidade Universitária, João Pessoa, PB 58051-900, Brazil.
Petrônio Filgueiras de Athayde FilhoDepartment of Chemistry, Federal University of Paraíba, Cidade Universitária, João Pessoa, PB 58051-900, Brazil.
Aurea WischralDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil.
Manoel Adrião Gomes FilhoDepartment of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil.
J Michael MathisDepartment of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
Universidade Federal Rural de Pernambuco · BRLouisiana State University · USUniversidade Federal da Paraíba · BRUniversity of North Texas Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, the cytotoxic effects of a 1,3-thiazolium-5-thiolate derivative of a mesoionic compound, MIH 2.4Bl, were assessed in the MCF-7 breast cancer cell line. The cytotoxic effects of MIH 2.4Bl were determined using a crystal violet assay. Using a dose-response curve, the IC

Indexed as

autophagybreast cancercancer therapychemotherapycytotoxicitymesoionic compoundmitochondria

Identifiers

PMID32782546
PMCPMC7399858
OpenAlexW3036374476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.