Evidence map›Paper›PMID 32782473›Full record

ArticleBiotechnology for biofuels2020

Modification of transcriptional factor ACE3 enhances protein production in

Yun Luo, Mari Valkonen, Raymond E Jackson, Jonathan M Palmer, Aditya Bhalla, Igor Nikolaev, Markku Saloheimo, Michael Ward

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 85 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mechanism of ZnBiotechnology for biofuels and bioproducts · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Induction of cellulase production by SrBioresources and bioprocessing · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yun Luo *DuPont Industrial Biosciences, Genencor Research Center, 925 Page Mill Road, Palo Alto, CA 94304 USA.ORCID 0000-0003-0761-6521
Mari Valkonen *VTT Technical Research Centre of Finland Ltd, P.O. Box 1000, FI-02044 VTT Espoo, Finland.
Raymond E JacksonDuPont Experimental Station, 200 Powder Mill Road, Wilmington, DE 19803 USA.
Jonathan M PalmerDuPont Industrial Biosciences, Genencor Research Center, 925 Page Mill Road, Palo Alto, CA 94304 USA.
Aditya BhallaDuPont Industrial Biosciences, Genencor Research Center, 925 Page Mill Road, Palo Alto, CA 94304 USA.
Igor NikolaevDuPont Industrial Biosciences, Genencor B.V., Willem Einthovenstraat 4, 2342 BH Oegstgeest, The Netherlands.
Markku SaloheimoVTT Technical Research Centre of Finland Ltd, P.O. Box 1000, FI-02044 VTT Espoo, Finland.
Michael WardDuPont Industrial Biosciences, Genencor Research Center, 925 Page Mill Road, Palo Alto, CA 94304 USA.
DuPont (United States) · USVTT Technical Research Centre of Finland · FIDuPont (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

resultsWe described an approach for producing high levels of secreted proteins by overexpression of a transcription factor ACE3 in

conclusionsThis study demonstrates that overexpression of ACE3 variants enables a high level of protein production in the absence of an inducer, and boosts protein production in the presence of an inducer. It is an efficient approach to increase protein productivity and to reduce manufacturing costs.

Indexed as

ACE3 transcription factorInducer-freeTrichoderma reesei

Identifiers

PMID32782473
PMCPMC7412840
OpenAlexW3047496849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.