Evidence map›Paper›PMID 32782464›Full record

ReviewJournal of the Intensive Care Society2020

The challenge of recognising sepsis: Future nanotechnology solutions.

Andrew Claxton, Lana Papafilippou, Marilena Hadjidemetriou, Kostas Kostarelos, Paul Dark

Abstract readReview
In one paragraph

Review in Journal of the Intensive Care Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Sepsis diagnosis and treatment using nanomaterials.Biomedical engineering letters · 2021
    Review
  7. Review
  8. Review
  9. Nanotools for Sepsis Diagnosis and Treatment.Advanced healthcare materials · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew ClaxtonNanomedicine Lab, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-5252-1487
Lana PapafilippouNanomedicine Lab, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Marilena HadjidemetriouNanomedicine Lab, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Kostas KostarelosNanomedicine Lab, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Paul DarkDepartment of Critical Care, Salford Royal Foundation Trust, Salford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent need to start anti-infective therapeutic interventions in suspected sepsis, and the lack of specific time-critical diagnostic information often lead to the widespread administration of broad-spectrum antimicrobial therapies, increasing the risk of unwanted patient harms and contributing to rising pathogen antimicrobial resistance. Nanotechnology, which involves engineering at the nanoscale, allows for the bespoke development of diagnostic solutions with multi-functionality and high sensitivity that has the potential to help provide time-critical information to make more accurate diagnoses and treatment decisions for sepsis. Nanotechnologies also have the potential to improve upon the current strategies used for novel biomarker discovery. Here we describe some of the current limitations to identifying sepsis and explore the potential role for nanotechnology solutions.

Indexed as

biomarkersdiagnosisinfectionnanotechnologySepsis

Identifiers

PMID32782464
PMCPMC7401438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.