ArticleTranslational psychiatry2020
Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- The role of the electroencephalogram (EEG) in determining the aetiology of psychosis: a systematic review and meta-analysis of diagnostic test accuracy.Schizophrenia research · 2025Pooled it
- Autoantibodies in patients with obsessive-compulsive disorder: a systematic review.Translational psychiatry · 2023Pooled it
- Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network.Molecular psychiatry · 2026Review
- Schizophrenia Spectrum Biomarkers Consortium: Establishment of a Biorepository for the Discovery of Quantitative Fluid Biomarkers.Schizophrenia bulletin · 2026Article
- High prevalence of CNS-directed autoantibodies in patients with schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- Linking peripheral low-grade inflammation and blood-cerebrospinal fluid barrier leakage in schizophrenia spectrum disorders - A retrospective analysis.Brain, behavior, & immunity - health · 2026Article
- Functional Brain Activity Associated With Intermittent Rhythmic Delta/Theta Activity: A Transdiagnostic Electroencephalography-Functional Magnetic Resonance Imaging Resting-State Study.Biological psychiatry global open science · 2026Article
- Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes.Brain, behavior, & immunity - health · 2025Article
- Autoimmune neuropsychiatric disorders manifesting with psychosis.The Journal of clinical investigation · 2025Review
- MR spectroscopic imaging and its association with EEG, CSF, and psychometric/neuropsychological findings in patients with suspected autoimmune psychosis spectrum syndromes.Acta neuropsychiatrica · 2025Article
- Frequency of autoimmune-associated exogenous psychoses in routine clinical care.Brain, behavior, & immunity - health · 2025Article
- Steroid-responsive autoimmune psychosis with cerebrospinal fluid-restricted oligoclonal bands and positive tissue-based assay findings: a case series of three patients.BMC psychiatry · 2025Article
- Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings.Frontiers in immunology · 2025Article
- Case Report: Acute polymorphic psychosis and NMDA-R IgG antibodies in serum: a follow-up case study.Frontiers in immunology · 2025Article
- Antibodies in neurological diseases: Established, emerging, explorative.Immunological reviews · 2024Review
- Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study.BMC psychiatry · 2024Article
- An exploratory study of the damage markers NfL, GFAP, and t-Tau, in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease.Translational psychiatry · 2024Article
- Blood-brain barrier dysfunction and folate and vitamin B12 levels in first-episode schizophrenia-spectrum psychosis: a retrospective chart review.European archives of psychiatry and clinical neuroscience · 2023Article
- SOX1 Antibody in a Patient With Serotonin Syndrome.Cureus · 2023Article
- Searching for Neuronal Antibodies in Psychiatric Diseases: Uncertain Findings and Implications.Neurology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The central role played by cerebrospinal-fluid (CSF) examinations including antineuronal autoantibody (Ab) testing is increasingly recognized in psychiatry. The rationale of this study was to present a multimodally investigated group of patients. In total, 992 patients were analyzed for CSF alterations: 456 patients with schizophreniform and 536 with affective syndromes. Ab measurement included testing for established antineuronal IgG-Abs against intracellular antigens in serum (Yo/Hu/Ri/cv2[CRMP5]/Ma1/Ma2/SOX1/TR[DNER]/Zic4/amphiphysin/GAD65) and for cell surface antigens in the CSF (NMDAR/AMPA-1/2-R/GABA-B-R/LGI1/CASPR2/DPPX). In 30 patients with "red flags" for autoimmune psychosis, "tissue tests" were performed. Additional diagnostics included MRI and EEG analyses. CSF white-blood-cell counts were increased in 4% and IgG indices in 2%; CSF-specific oligoclonal bands were detected in 4%; overall, 8% displayed signs of neuroinflammation. In addition, 18% revealed increased albumin quotients. Antineuronal Abs against intracellular antigens were detected in serum in 0.6%. Antineuronal Abs against established cell surface antigens were detected in serum of 1% and in the CSF of 0.3% (CSF samples were only questionably positive). Abnormal IgG binding in "tissue tests" was detected in serum of 23% and in CSF of 27%. In total, 92% of the Ab-positive patients demonstrated at least one sign of brain involvement in additional diagnostics using CSF, MRI, EEG, and FDG-PET. In summary, CSF basic analyses revealed signs of blood-brain-barrier dysfunction and neuroinflammation in relevant subgroups of patients. Established antineuronal IgG-Abs were rare in serum and even rarer in the CSF. "Tissue tests" revealed frequent occurrences of Ab-binding; therefore, novel antineuronal Abs could play a relevant role in psychiatry.
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