ReviewBiological psychiatry2021
Neural Correlates Associated With Suicide and Nonsuicidal Self-injury in Youth.
Review in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
105 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt.Frontiers in psychiatry · 2026Pooled it
- Structural connectivity abnormalities in suicidal thoughts and behaviours: a meta-analysis.Translational psychiatry · 2025Pooled it
- Why do adolescents attempt suicide? Insights from leading ideation-to-action suicide theories: a systematic review.Translational psychiatry · 2024Pooled it
- A bibliometric analysis and visualization of non-suicidal self-injury in adolescents.Frontiers in psychiatry · 2024Pooled it
- Suicidal ideation and cognitive function: a comparative study in adolescents with unipolar versus bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Abnormal Dynamic Functional Connectivity Within the Fronto-Limbic Network Mediates the Association Between Depressive Symptoms and Non-Suicidal Self-Injury in Adolescents.CNS neuroscience & therapeutics · 2026Article
- Longitudinal changes in amygdala-supplementary motor area connectivity and their association with recurrent self-harm in adolescents with mood disorders.BMC psychiatry · 2026Article
- Site-specific N-glycosylation alterations in serum proteins across subtypes of adolescent depressive disorder.BMC psychiatry · 2026Article
- Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression.Molecular psychiatry · 2026Article
- A Comparative Analysis of Cortical Thickness in Female Youth With Non-Suicidal Self-Injury.Psychiatry investigation · 2026Article
- Sad emotion processing-related theta oscillation patterns link suicide attempt to childhood trauma in depression: evidence from MEG.Translational psychiatry · 2026Article
- Frequency of bullying modulates amygdala response during social exclusion in participants with non-suicidal self-injury.European child & adolescent psychiatry · 2026Article
- Altered functional brain network in adolescents with non-suicidal self-injury: a resting-state EEG study.BMC psychiatry · 2026Article
- Accelerated Magnetic Seizure Therapy for Non-Suicidal Self-Injury in Adolescents With Bipolar Depression.CNS neuroscience & therapeutics · 2026Article
- Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.Alpha psychiatry · 2026Article
- Association between Apolipoprotein B (ApoB) and suicidal ideation: a cross-sectional study and Mendelian randomization analysis.Annals of general psychiatry · 2026Article
- High-gamma tACS may regulate brain network connectivity to alleviate symptoms in female adolescent non-suicidal self-injury: a preliminary TMS-EEG pilot study.BMC psychiatry · 2026Article
- Suicide attempt history, childhood trauma, and functional brain network alterations in major depressive disorder: a resting-state functional connectivity-based multivariate pattern analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural Representations of Death-Related Concepts Identify Conceptual Alteration of Self in Suicidal Youth.Human brain mapping · 2026Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging studies reporting structural and functional neural correlates of STBs and NSSI in youth to 1) elucidate shared and independent neural alternations, 2) clarify how developmental processes may interact with neural alterations to confer risk, and 3) provide recommendations based on convergence across studies. Forty-seven articles were reviewed (STBs = 27; NSSI = 20), and notably, 63% of STB articles and 45% of NSSI articles were published in the previous 3 years. Structural magnetic resonance imaging research suggests reduced volume in the ventral prefrontal and orbitofrontal cortices among youth reporting STBs, and there is reduced anterior cingulate cortex volume related to STBs and NSSI. With regard to functional alterations, blunted striatal activation may characterize STB and NSSI youth, and there is reduced frontolimbic task-based connectivity in suicide ideators and attempters. Resting-state functional connectivity findings highlight reduced positive connectivity between the default mode network and salience network in attempters and show that self-injurers exhibit frontolimbic alterations. Together, suicidal and nonsuicidal behaviors are related to top-down and bottom-up neural alterations, which may compromise approach, avoidance, and regulatory systems. Future longitudinal research with larger and well-characterized samples, especially those integrating ambulatory stress assessments, will be well positioned to identify novel targets that may improve early identification and treatment for youth with STBs and NSSI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.