Evidence map›Paper›PMID 32782015›Full record

ArticleSystematic reviews2020

Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials.

Séphora Louyse Silva Aquino, Aline Tuane Oliveira Cunha, Josivan Gomes Lima, Karine Cavalcanti Maurício Sena-Evangelista, Antonio Gouveia Oliveira, Ricardo Ney Cobucci, Lucia Fatima Campos Pedrosa

Open access · goldAbstract read
In one paragraph

Article in Systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Séphora Louyse Silva AquinoPostgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil.
Aline Tuane Oliveira CunhaCollaborative Researcher in Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000-Lagoa Nova, Natal, CEP 59078970, Brazil.
Josivan Gomes LimaDepartment of Clinical Medicine, Endocrine Unit, Federal University of Rio Grande do Norte, Natal, RN, 59010-180, Brazil.
Karine Cavalcanti Maurício Sena-EvangelistaDepartment of Nutrition, Federal University of Rio Grande do Norte, Av.Sen. Salgado Filho, n° 3000, Lagoa Nova, Natal, RN, CEP 59078-970, Brazil.
Antonio Gouveia OliveiraDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, 59012570, Brazil.
Ricardo Ney CobucciPostgraduate Program in Biotechnology and Medicine School, Potiguar University-UnP, Natal, RN, 59056-000, Brazil.
Lucia Fatima Campos PedrosaPostgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil. lfcpedrosa@gmail.com.ORCID 0000-0002-5436-5115
Universidade Federal do Rio Grande do Norte · BRUniversidade Potiguar · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS.

methodsEMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol-HDL-C) is this review's primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran's Q test and the I DISCUSSION: This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration number CRD42019123212.

Indexed as

DyslipidemiasMetabolic SyndromeObesity, AbdominalAdultBlood PressureDietary SupplementsFastingGlucoseHumansMeta-Analysis as TopicRandomized Controlled Trials as TopicSystematic Reviews as TopicVitamin DGlucoseVitamin DMetabolic syndromeRandomized controlled trialsSystematic reviewVitamin D supplementation

Identifiers

PMID32782015
PMCPMC7418408
OpenAlexW3048772908

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.