Evidence map›Paper›PMID 32781942›Full record

ArticleStroke2020

Sickle Cell Trait and Risk of Ischemic Stroke in Young Adults.

Rebecca V Zhang, Kathleen A Ryan, Haley Lopez, Marcella A Wozniak, Michael S Phipps, Carolyn A Cronin, John W Cole, Tara M Dutta, Prachi Mehndiratta, Melissa Motta and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rebecca V ZhangDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Kathleen A RyanDepartment of Medicine (K.A.R.), University of Maryland School of Medicine, Baltimore.
Haley LopezDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Marcella A WozniakDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Michael S PhippsDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Carolyn A CroninDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
John W ColeDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Tara M DuttaDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Prachi MehndirattaDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Melissa MottaDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
José G MerinoDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
Steven J KittnerDepartment of Neurology (R.V.Z., H.L., M.A.W., M.S.P., C.A.C., J.W.C., T.M.D., P.M., M.M., J.G.M., S.J.K.), University of Maryland School of Medicine, Baltimore.
University of Maryland, Baltimore · US

Funding

Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI ONUKWUGHA, EBERECHUKWU · 2002 to 2009
$20.2M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Genetics of Early Onset-StrokeR01NS045012 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2003 to 2007
$3.3M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
NCRR NIH HHS M01 RR016500NIDDK NIH HHS P30 DK072488NINDS NIH HHS R01 NS045012NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150
6 · The paper itself

Abstract

background and purposeApproximately 8% of Blacks have sickle cell trait (SCT), and there are conflicting reports from recent cohort studies on the association of SCT with ischemic stroke (IS). Most prior studies focused on older populations, with few data available in young adults.

methodsA population-based case-control study of early-onset IS was conducted in the Baltimore-Washington region between 1992 and 2007. From this study, 342 Black IS cases, ages 15 to 49, and 333 controls without IS were used to examine the association between SCT and IS. Each participant's SCT status was established by genotyping and imputation. For analysis, χ

resultsParticipants with SCT (n=55) did not differ from those without SCT (n=620) in prevalence of hypertension, previous myocardial infarction, diabetes mellitus, and current smoking status. Stroke cases had increased prevalence in these risk factors compared with controls. We did not find an association between SCT and early-onset IS in our overall population (odds ratio=0.9 [95% CI, 0.5-1.7]) or stratified by sex in males (odds ratio=1.26 [95% CI, 0.56-2.80]) and females (odds ratio=0.67 [95% CI, 0.28-1.69]).

conclusionsOur data did not find evidence of increased risk of early-onset stroke with SCT.

Indexed as

AdolescentAdultAge of OnsetBaltimoreBlack or African AmericanBrain IschemiaCase-Control StudiesDiabetes ComplicationsDistrict of ColumbiaFemaleGenotypeHumansHypertensionMaleMiddle AgedMyocardial Infarctionodds ratioprevalencerisk factorssickle cell traitstrokeyoung adult

Identifiers

PMID32781942
PMCPMC7453974
OpenAlexW3048773952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.