Evidence map›Paper›PMID 32781940›Full record

Trial reportJournal of the American Heart Association2020

Effects of Inhibition of Nitric Oxide Synthase on Muscular Arteries During Exercise: Nitric Oxide Does Not Contribute to Vasodilation During Exercise or in Recovery.

Kevin O'Gallagher, Husain Shabeeh, Shahzad Munir, Ali Roomi, Benyu Jiang, Antoine Guilcher, Sally Brett, Philip Chowienczyk

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Increased cGMP improves microvascular exercise training adaptations in diet-induced obesity.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kevin O'GallagherCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Husain ShabeehCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Shahzad MunirCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Ali RoomiCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Benyu JiangCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Antoine GuilcherCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Sally BrettCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
Philip ChowienczykCardiovascular Division Department of Clinical Pharmacology King's College London School of Medicine St Thomas' Hospital London United Kingdom.
King's College London · GBSt Thomas' Hospital · GB

Funding

British Heart Foundation PG/14/52/30873Department of HealthMedical Research Council MR/R017751/1
6 · The paper itself

Abstract

Background Basal release of nitric oxide (NO) from the vascular endothelium regulates the tone of muscular arteries and resistance vasculature. Effects of NO on muscular arteries could be particularly important during exercise when shear stress may stimulate increased NO synthesis. Methods and Results We investigated acute effects of NO synthase inhibition on exercise hemodynamics using N

Indexed as

AdultArterial PressureArteriesCardiac OutputCross-Over StudiesEnzyme InhibitorsExerciseExercise TestFemaleFemoral ArteryHumansMaleMuscle, SkeletalNitric OxideNitric Oxide Synthaseomega-N-MethylarginineEnzyme InhibitorsNitric OxideNitric Oxide Synthaseomega-N-MethylargininePlacebosexercise physiologynitric oxidenitric oxide synthase

Identifiers

PMID32781940
PMCPMC7660814
OpenAlexW3048669727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.