Evidence map›Paper›PMID 32781764›Full record

ArticleInternational journal of molecular sciences2020

Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis.

Mette G Christensen, Nanna Johnsen, Marianne Skals, Aimi D M Hamilton, Peter Rubak, Anne-Mette Hvas, Helle Praetorius

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Special Issue ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mette G ChristensenDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Nanna JohnsenDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Marianne SkalsDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Aimi D M HamiltonDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
Peter RubakClinic for Diagnostics, Aalborg University Hospital, 9000 Aalborg, Denmark.
Anne-Mette HvasDepartment of Clinical Biochemistry, Aarhus University Hospital, 8000 Aarhus C, Denmark.
Helle PraetoriusDepartment of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.ORCID 0000-0002-0970-5061
Aarhus University · DKAalborg University Hospital · DKAarhus University Hospital · DK

Funding

Det Frie Forskningsråd DFF-1331-00203A
6 · The paper itself

Abstract

Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream of the host. One of the hallmarks of sepsis is early thrombocyte activation with a following fall in circulating thrombocytes as a result of intravascular aggregation and sequestering of thrombocytes in the major organs. Development of a thrombocytopenic state is associated with a poorer outcome of sepsis. Uropathogenic

Indexed as

Adenosine MonophosphateAnimalsBacterial ToxinsBlood PlateletsDeoxyadenine NucleotidesDisease Models, AnimalEscherichia coli ProteinsHemolysin ProteinsHumansMaleMice, Inbred BALB CReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12SepsisTreatment OutcomeUrinary Tract Infections2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphateAdenosine MonophosphateBacterial ToxinscangrelorDeoxyadenine NucleotidesEscherichia coli ProteinsHemolysin ProteinsHlya protein, E coliReceptors, Purinergic P2Y1Receptors, Purinergic P2Y12Escherichia coliHlyAP2Y1P2Y12sepsisthrombocytes

Identifiers

PMID32781764
PMCPMC7460651
OpenAlexW3047613122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.