ReviewMolecules (Basel, Switzerland)2020
Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Water-Mediated Arylation of an Imine Intermediate: A Catalyst- and Promoter-Free Three-Component Coupling in a Mortar Reactor.ACS omega · 2026Article
- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening.Molecules (Basel, Switzerland) · 2025Article
- Recent Advances in the Enzymatic Synthesis of Polyester.Polymers · 2022Review
- Organocatalytic Enantioselective α-Nitrogenation of α,α-Disubstituted Aldehydes in the Absence of a Solvent.The Journal of organic chemistry · 2022Article
- Mechanochemistry: New Tools to Navigate the Uncharted Territory of "Impossible" Reactions.ChemSusChem · 2022Review
- Synthesis of a Pyrrolo[1,2-Molecules (Basel, Switzerland) · 2022Article
- The Mechanochemical Synthesis and Activation of Carbon-Rich π-Conjugated Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Efficacy of Selenourea Organocatalysts in Asymmetric Michael Reactions under Standard and Solvent-Free Conditions.Molecules (Basel, Switzerland) · 2021Article
- Structure-Based Designing, Solvent Less Synthesis of 1,2,3,4-Tetrahydropyrimidine-5-carboxylate Derivatives: A Combined In Vitro and In Silico Screening Approach.Molecules (Basel, Switzerland) · 2021Article
- Sulfamic acid pyromellitic diamide-functionalized MCM-41 as a multifunctional hybrid catalyst for melting-assisted solvent-free synthesis of bioactive 3,4-dihydropyrimidin-2-(1H)-ones.Scientific reports · 2021Article
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2 authors.
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Abstract
One central challenge for XXI century chemists is the development of sustainable processes that do not represent a risk either to humanity or to the environment. In this regard, the search for more efficient and clean alternatives to achieve the chemical activation of molecules involved in chemical transformations has played a prominent role in recent years. The use of microwave or UV-Vis light irradiation, and mechanochemical activation is already widespread in many laboratories. Nevertheless, an additional condition to achieve "green" processes comes from the point of view of so-called atom economy. The removal of solvents from chemical reactions generally leads to cleaner, more efficient and more economical processes. This review presents several illustrative applications of the use of sustainable protocols in the synthesis of organic compounds under solvent-free reaction conditions.
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