ArticleMarine drugs2020
From Food Waste to Innovative Biomaterial: Sea Urchin-Derived Collagen for Applications in Skin Regenerative Medicine.
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Marine collagen for regenerative medicine: Structure-function advantages, limitations, and translational pathways.Bioactive materials · 2026Review
- Methacrylation of Fibrillar Sea Urchin Collagen: Production of Sustainable, Stable, and Functional Hydrogels.ACS omega · 2026Article
- Unraveling the Potential ofBiomacromolecules · 2026Article
- Collagen-Based 3D Scaffolds from Sea Urchin Food Waste for Skeletal Muscle Tissue Engineering.Animals : an open access journal from MDPI · 2026Article
- The Fibrillar Collagens of Bony Fish: Genes, Proteins, and Biomedical Applications.Sub-cellular biochemistry · 2026Review
- Collagen from Marine Sources for Potential Application in Wound Treatment.Progress in molecular and subcellular biology · 2026Review
- Collagen-elastin dermal scaffolds enhance tissue regeneration and reduce scarring in preclinical models.Materials today. Bio · 2025Article
- Seas of Renewal: Turning Sea Urchin Waste into Polyhydroxynaphtoquinone-Collagen Biomaterials for Regenerative Medicine.Marine biotechnology (New York, N.Y.) · 2025Article
- Marine-Derived Collagen and Chitosan: Perspectives on Applications Using the Lens of UN SDGs and Blue Bioeconomy Strategies.Marine drugs · 2025Review
- Free and encapsulated stem cells for skin regeneration.BioImpacts : BI · 2025Review
- How Significant Are Marine Invertebrate Collagens? Exploring Trends in Research and Innovation.Marine drugs · 2024Review
- Extraction and Purification of Biopolymers from Marine Origin Sources Envisaging Their Use for Biotechnological Applications.Marine biotechnology (New York, N.Y.) · 2024Review
- Sea Urchin Food Waste into Bioactives: Collagen and Polyhydroxynaphtoquinones fromMarine drugs · 2024Article
- The Characterization and Cytotoxic Evaluation ofMarine drugs · 2024Article
- Mutable Collagenous Tissue: A Concept Generator for Biomimetic Materials and Devices.Marine drugs · 2024Review
- Sea food by-products valorization for biomedical applications: evaluation of their wound regeneration capabilities in anFrontiers in veterinary science · 2024Article
- From Water for Water: PEDOT:PSS-Chitosan Beads for Sustainable Dyes Adsorption.Gels (Basel, Switzerland) · 2023Article
- Recent Advances in the Development of Biomimetic Materials.Gels (Basel, Switzerland) · 2023Review
- Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats.Marine drugs · 2023Article
- A Second Life for Seafood Waste: Therapeutical Promises of Polyhydroxynapthoquinones Extracted from Sea Urchin by-Products.Antioxidants (Basel, Switzerland) · 2023Article
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Authors and funding
14 authors.
Funding
Abstract
Collagen-based skin-like scaffolds (CBSS) are promising alternatives to skin grafts to repair wounds and injuries. In this work, we propose that the common marine invertebrate sea urchin represents a promising and eco-friendly source of native collagen to develop innovative CBSS for skin injury treatment. Sea urchin food waste after gonad removal was here used to extract fibrillar glycosaminoglycan (GAG)-rich collagen to produce bilayer (2D + 3D) CBSS. Microstructure, mechanical stability, permeability to water and proteins, ability to exclude bacteria and act as scaffolding for fibroblasts were evaluated. Our data show that the thin and dense 2D collagen membrane strongly reduces water evaporation (less than 5% of water passes through the membrane after 7 days) and protein diffusion (less than 2% of BSA passes after 7 days), and acts as a barrier against bacterial infiltration (more than 99% of the different tested bacterial species is retained by the 2D collagen membrane up to 48 h), thus functionally mimicking the epidermal layer. The thick sponge-like 3D collagen scaffold, structurally and functionally resembling the dermal layer, is mechanically stable in wet conditions, biocompatible in vitro (seeded fibroblasts are viable and proliferate), and efficiently acts as a scaffold for fibroblast infiltration. Thus, thanks to their chemical and biological properties, CBSS derived from sea urchins might represent a promising, eco-friendly, and economically sustainable biomaterial for tissue regenerative medicine.
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