Evidence map›Paper›PMID 32781624›Full record

ArticleMetabolites2020

A Multilevel Bayesian Approach to Improve Effect Size Estimation in Regression Modeling of Metabolomics Data Utilizing Imputation with Uncertainty.

Christopher E Gillies, Theodore S Jennaro, Michael A Puskarich, Ruchi Sharma, Kevin R Ward, Xudong Fan, Alan E Jones, Kathleen A Stringer

Abstract read
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Subtle to significant: Enhancing heaviness perception with stochastic resonance.Journal of experimental psychology. Human perception and performance · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christopher E GilliesDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Theodore S JennaroDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Michael A PuskarichDepartment of Emergency Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Ruchi SharmaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Kevin R WardDepartment of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Xudong FanMichigan Institute for Data Science (MIDAS), Office of Research, University of Michigan, Ann Arbor, MI 48109, USA.
Alan E JonesDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Kathleen A StringerMichigan Center for Integrative Research in Critical Care (MCIRCC), University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0238-7774

Funding

L-carnitine Treatment for Vasopressor Dependent Septic ShockR01GM103799 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI JONES, ALAN E · 2012 to 2016
$3.1M
Translational Metabolomics in Critical CareR35GM136312 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KATHLEEN A STRINGER · 2020 to 2026
$2.8M
L-Carnitine Pharmacometabolomics in Sepsis (CaPS)R01GM111400 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STRINGER, KATHLEEN A · 2016 to 2019
$1.2M
Platelet activation in septic shockK23GM113041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI PUSKARICH, MICHAEL A. · 2015 to 2018
$763k
Rapid breath analysis for acute respiratory distress syndrome diagnosticsR21HL139156 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAN, XUDONG · 2018 to 2019
$412k
Michigan Center for Integrative Research in Critical Care NAMichigan Institute for Data Science Propelling Original Data ScienceMichigan Translation and Commercialization (MTRAC) for Life Sciences Hub NANHLBI NIH HHS 1-R21-HL-139156-01NIGMS NIH HHS K23GM113041NIGMS NIH HHS R01GM103799NIGMS NIH HHS R01 GM111400NIGMS NIH HHS R01GM111400NIGMS NIH HHS R35 GM136312NIH Center for Accelerated Innovations at Cleveland Clinic NCAI-17-7-APP-UMICH-Fan
6 · The paper itself

Abstract

To ensure scientific reproducibility of metabolomics data, alternative statistical methods are needed. A paradigm shift away from the

Indexed as

Bayesian statisticshierarchical modelingimputationmissing valuesmultiple test correctionsnuclear magnetic resonance spectroscopy

Identifiers

PMID32781624
PMCPMC7465156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.